The skin, the largest organ in the body, provides the first line of defense against the environment both as a physical barrier and as a key immunological component. Toll-like receptors (TLRs) serve as signaling molecules that recognize pathogenassociated molecular patterns (PAMPs) as well as damage-associated molecular patterns (DAMPs), and are expressed by various skin cells including keratino...

Abstract Introduction: Non-melanoma scalp skin cancers (NMSCs) including squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs) are common. To manage such cancers, especially SCCs, more attention should be paid to their invasive characteristics. Mortality surveillance of SCCs and BCCs of scalp helps to choose proper approaches. Methods: The current retrospective, descriptive study w...

Abstract Introduction: Non-melanoma scalp skin cancers (NMSCs) including squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs) are common. To manage such cancers, especially SCCs, more attention should be paid to their invasive characteristics. Mortality surveillance of SCCs and BCCs of scalp helps to choose proper approaches. Methods: The current retrospective, descriptive study w...

was the cause of their melanoma, seven (11%) blamed sunbed use and 10 more (16%) did not exclude the possibility that exposure to UV radiation was the cause of their melanoma (Table 1). Males attributed their melanoma directly to the sun or sunbeds more often (32%) than females (22%). Patients who were more susceptible to the sun (fairskinned, blue eyes, blond hair) and had been sunburned frequ...

Non-melanoma skin cancer (NMSC) represents the most frequent type of cancers among Caucasians. Consisting basal cell carcinoma (BCC) and squamous (SCC), which both develop in epidermis skin. The incidence NMSC has increased by 33% over past 10 years. steadily increasing number cases continue to cause burden society health care. Vitiligo is an autoimmune disease characterized white depigmented l...

The use of chemical and physical sunscreening agents has increased dramatically during the last two to three decades as an effective means of preventing sunbum. The use of high sunprotection factor sunscreens has also been widely promoted for the prevention of skin cancer, including melanoma. Whereas sunscreens are undoubtedly effective in preventing sunbum, their efficacy in preventing skin ca...

BACKGROUND Skin cancer is the most common cancer in the United States. Increasing evidence suggests that screening for malignant melanoma is effective, but its cost-effectiveness has not been determined. OBJECTIVE We attempted to determine the effectiveness and costs of a visual screen to diagnose malignant melanoma in high-risk persons. METHODS We developed a decision analysis comparing no...

Melanoma is an aggressive form of skin cancer resulting from the malignant transformation melanocytes. Recent therapeutic approaches, including targeted therapy and immunotherapy, have improved prognosis outcome melanoma patients. BRAF one most frequently mutated oncogenes recognised in melanoma. The frequent oncogenic mutations consist a single point mutation at codon 600 (mostly V600E) that l...

Melanoma is one of the most dangerous forms of cancer. The five-year survival rate is 98% if it is detected early. However, this rate plummets to 62% for regional disease and below 15% when tumors have spread to distant sites. Furthermore, the incidence of melanoma has been rising by about 3% per year, while the incidence of most common cancers is decreasing. A handful of targeted therapies hav...

Melanocortin 1 receptor (MC1R) gene variants are associated with red hair and fair skin color. We assessed the associations of common MC1R genotypes with the risks of 3 types of skin cancer simultaneously in a nested case-control study within the Nurses' Health Study (219 melanoma, 286 squamous cell carcinoma (SCC), and 300 basal cell carcinoma (BCC) cases, and 873 controls). We found that the ...