نتایج جستجو برای: nnos

تعداد نتایج: 2006  

2017
Xing Jin Zhang-Feng Yu Fang Chen Guang-Xian Lu Xin-Yuan Ding Lin-Jun Xie Jian-Tong Sun

Active adult neurogenesis produces new functional neurons, which replace the lost ones and contribute to brain repair. Promoting neurogenesis may offer a therapeutic strategy for human diseases associated with neurodegeneration. Here, we report that endogenous neuronal nitric oxide synthase (nNOS) for neural stem cells (NSCs) or progenitors positively regulates neurogenesis. nNOS repression exh...

Journal: :Circulation research 2005
Yu-Long Li Yi-Fan Li Dongmei Liu Kurtis G Cornish Kaushik P Patel Irving H Zucker Keith M Channon Harold D Schultz

Our previous studies showed that decreased nitric oxide (NO) production enhanced carotid body (CB) chemoreceptor activity in chronic heart failure (CHF) rabbits. In the present study, we investigated the effects of neuronal NO synthase (nNOS) gene transfer on CB chemoreceptor activity in CHF rabbits. The nNOS protein expression and NO production were suppressed in CBs (P<0.05) of CHF rabbits, b...

Journal: :American journal of physiology. Cell physiology 1997
Sushanta Chakder Alok Bandyopadhyay Satish Rattan

Nitric oxide synthase (NOS) has been characterized in different tissues, and its localization has been suggested in different neuronal tissues, including the myenteric neurons and other nonneuronal cells. The present study examined the distribution of the neuronal NOS (nNOS) mRNA in different tissues of the opossum gastrointestinal tract, internal anal sphincter (IAS) smooth muscle cells, and m...

Journal: :Journal of andrology 2009
Ben A Weissman Chantal M Sottas Michael Holmes Ping Zhou Costantino Iadecola Dianne O Hardy Ren-Shan Ge Matthew P Hardy

The hormonal changes associated with immobilization stress (IMO) include a swift increase in corticosterone (CORT) concentration and a decrease in circulating testosterone (T) levels. There is evidence that the production of the short-lived neuromodulator nitric oxide (NO) is increased during stress in various tissues, including the brain. NO also suppresses the biosynthesis of T. Both the indu...

Journal: :General physiology and biophysics 2002
D Kluchová R Klimcík P Kloc

The NADPH-diaphorase (NADPH-d) staining method is widely used in the investigation of both the central and peripheral nervous systems. Neuronal nitric oxide synthase (nNOS) has previously been shown to be responsible for the NADPH-d activity in neurons. However, NADPH-d activity does not always fully represent the enzyme nNOS. We investigated the distribution of NADPH-d activity and nNOS protei...

Journal: :Investigative ophthalmology & visual science 2001
C Ding B Walcott K T Keyser

PURPOSE To determine the expression patterns of the vesicular acetylcholine transporter (VAChT), tyrosine hydroxylase (TH) and neuronal nitric oxide synthase (nNOS) in the pterygopalatine ganglion (PPG) and the exorbital lacrimal gland of normal mice. METHODS Mouse PPG and lacrimal glands were processed for single- and double-labeled indirect immunofluorescence studies. Slides were examined w...

Journal: :The Journal of biological chemistry 2001
K Panda S Ghosh D J Stuehr

Neuronal nitric oxide synthase (nNOS) is composed of an oxygenase domain that binds heme, (6R)-tetrahydrobiopterin, and Arg, coupled to a reductase domain that binds FAD, FMN, and NADPH. Activity requires dimeric interaction between two oxygenase domains and calmodulin binding between the reductase and oxygenase domains, which triggers electron transfer between flavin and heme groups. We constr...

Journal: :The Journal of clinical investigation 2007
Naoki Suzuki Norio Motohashi Akiyoshi Uezumi So-ichiro Fukada Tetsuhiko Yoshimura Yasuto Itoyama Masashi Aoki Yuko Miyagoe-Suzuki Shin'ichi Takeda

Forkhead box O (Foxo) transcription factors induce muscle atrophy by upregulating the muscle-specific E3 ubiquitin ligases MuRF-1 and atrogin-1/MAFbx, but other than Akt, the upstream regulators of Foxos during muscle atrophy are largely unknown. To examine the involvement of the dystrophin glycoprotein complex (DGC) in regulation of Foxo activities and muscle atrophy, we analyzed the expressio...

Journal: :Learning & memory 2013
Eloisa Pavesi Scott A Heldt Max L Fletcher

Experience-induced changes associated with odor learning are mediated by a number of signaling molecules, including nitric oxide (NO), which is predominantly synthesized by neuronal nitric oxide synthase (nNOS) in the brain. In the current study, we investigated the role of nNOS in the acquisition and retention of conditioned olfactory fear. Mice lacking nNOS received six training trials, each ...

2001
Frédéric Lopez Géraldine Ferjoux Pierre Cordelier Nathalie Saint-Laurent Jean-Pierre Estève Nicole Vaysse Louis Buscail Christiane Susini

Somatostatin receptor sst2 is an inhibitory G protein-coupled receptor, which inhibits normal and tumor cell growth by a mechanism involving the tyrosine phosphatase SHP-1. We reported previously that SHP-1 associates transiently with and is activated by sst2 and is a critical component for sst2 growth inhibitory signaling. Here, we demonstrate that in Chinese hamster ovary cells expressing sst...

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