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تعداد نتایج: 827 فیلتر نتایج به سال:
Notch signalling plays an important role in endocrine development, through its target gene Hes1. Hes1, a bHLH transcriptional repressor, influences progenitor cell proliferation and differentiation. Recently, Hes1 was shown to be expressed in the thyroid and regulate expression of the sodium iodide symporter (Nis). To investigate the role of Hes1 for thyroid development, we studied thyroid morp...
Corresponding Author: Dr. Arsham Borumand Saeid, Department of Mathematics, Shahid Bahonar University of Kerman, Kerman, Iran, email: [email protected] 1446 Ideal Theory of BCH-Algebras 1A. Borumand Saeid, 2A. Namdar and 3R.A. Borzooei Department of Mathematics, Shahid Bahonar University of Kerman, Kerman, Iran Department of Mathematics, Islamic Azad University Zarin Dasht Branch, Iran Depar...
Transformation of epithelial cells by high-risk human papillomavirus (hrHPV) types can lead to anogenital carcinomas, particularly cervical cancer, and oropharyngeal cancers. This process is associated with DNA methylation alterations, often affecting tumour suppressor gene expression. This study aimed to comprehensively unravel genome-wide DNA methylation events linked to a transforming hrHPV-...
The Chinese medicinal herb Sorbaria sorbifolia, native to Changbai Mountain, can induce apoptosis in HepG-2 cells. We studied the mechanism by which 5, 2', 4'-trihydroxy-6,7, 5'-trimethoxyflavone (TTF1) isolated from acetic ether extracts of Sorbaria sorbifolia induces apoptosis in HepG-2 cells. The results showed that TTF1 both inhibited cell growth and induced apoptosis. RT-PCR and Western bl...
D rosophila may be small, but you can’t accuse them of lacking heart. Unless they’re missing the transcription factor Tinman, that is, in which case they fail to form a heart during embryogenesis (1, 2) or, if tinman is deleted later in development, they fail to maintain adult cardiac function (3). Qian et al. now reveal how Tinman works in conjunction with the small GTPase Cdc42 to regulate th...
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