نتایج جستجو برای: nk cytotoxicity

تعداد نتایج: 63985  

Journal: :Journal of reproductive immunology 2012
Najmeh Karami Mehri G Boroujerdnia Roshan Nikbakht Ali Khodadadi

Recent studies support the concept that NK cells play an important role in the success or failure of embryo implantation. Recurrent spontaneous abortion (RSA) is the most common complication of pregnancy. Some couples suffer from infertility of unknown cause. In vitro fertilization (IVF) is one of the useful treatment methods used for treatment of this type for infertility with variable outcome...

2016
Wolfgang Merkt Hanns-Martin Lorenz Carsten Watzl

BACKGROUND Rituximab has broad and increasing application in rheumatic diseases. It is known from lymphoma studies that natural killer (NK) cells can lyse rituximab-coated transformed B cells. However, the role of NK cells in mediating rituximab-induced depletion of non-malignant B cells is unknown. The purpose of this study was to provide fundamental data on rituximab-mediated effects on NK ce...

2015
Xing Zhao Narendiran Rajasekaran Cariad Chester Atsushi Yonezawa Suparna Dutt Matt Coffey Holbrook E Kohrt

Methods Here we investigated the direct effect of reovirus on NK cell mediated ADCC against the EGFR (Epidermal Growth Factor) positive colorectal cancer cell line: DLD-1 (KRAS mut). NK cells isolated from human PBMCs were cultured with 1pfu of reovirus for 12 hrs. These reovirus treated NK cells were co-cultured with DLD-1 cells coated with increasing concentrations anti-EGFR antibody cetuxima...

2014
H Klingemann

Methods Collecting NK cells form donors requires them to undergo leukapheresis with subsequent removal of CD3+ lymphocytes (to prevent GvHD) and expansion and activation of the NK cell enriched fraction with IL-2. In contrast, the continuously growing NK cell line NK-92 can be easily expanded to clinical scale in bioreactors. The broad cytotoxicity of NK-92 is due to the lack of most of the KIR...

Journal: :Journal of immunology 2003
Isabel Barao Dorothy Hudig Joao L Ascensao

Optimal differentiation of cytotoxic NK cells is important to provide protective innate immunity to patients after bone marrow transplantation. In vitro differentiation of CD56(+)CD3(-) NK cells takes weeks and is supported by several cytokines, including IL-2, IL-7, and IL-15, and thus can be useful for immunotherapy. However, IL-2 therapy is problematic in vivo, and NK cells differentiated in...

2014
Xiao Mou Yuepeng Zhou Peng Jiang Tong Zhou Qian Jiang Chengcheng Xu Hongli Liu Tingting Zheng Guoyue Yuan Yanyun Zhang Deyu Chen Chaoming Mao

The activating immunoreceptor NKG2D (natural killer group 2, member D) and its ligands play important roles in the innate and adaptive immune responses. UL16-binding protein 3 (ULBP3), an NKG2D ligand, is overexpressed on certain epithelial tumor cells. In this study, we investigated the effect of ULBP3 expression on the cytotoxic activity of natural killer (NK) cells. ULBP3 were measured by fl...

Journal: :International immunology 2012
Ilwoong Hwang Tianxiang Zhang Jeannine M Scott Ae Ra Kim Taehyung Lee Tejaswi Kakarla Ahrom Kim John B Sunwoo Sungjin Kim

NK cells respond to tumor and virus-infected cells directly through several activation receptors, including natural cytotoxicity receptors, or indirectly through the activating Fc receptor CD16 for antibody-coated cells. Triggering of NK-cell effector functions through these receptors depends on physically associated transmembrane signaling adaptors, such as FcRγ (also known as FcεRIγ) and CD3ζ...

2013
Nina Shah Beatriz Martin-Antonio Hong Yang Stephanie Ku Dean A. Lee Laurence J. N. Cooper William K. Decker Sufang Li Simon N. Robinson Takuya Sekine Simrit Parmar John Gribben Michael Wang Katy Rezvani Eric Yvon Amer Najjar Jared Burks Indreshpal Kaur Richard E. Champlin Catherine M. Bollard Elizabeth J. Shpall

Natural killer (NK) cells are important mediators of anti-tumor immunity and are active against several hematologic malignancies, including multiple myeloma (MM). Umbilical cord blood (CB) is a promising source of allogeneic NK cells but large scale ex vivo expansion is required for generation of clinically relevant CB-derived NK (CB-NK) cell doses. Here we describe a novel strategy for expandi...

Journal: :Nihon Ika Daigaku zasshi 1989
A Murata

The author took interest in the existence of effector cells which had natural killer (NK) activity on the lung, in other words organ-associated NK cells, compared the augmented effect of pulmonary NK activity by poly I:C with that of spleen NK activity, and also investigated the effect of activated pulmonary NK cells on established pulmonary metastasis. It was shown that pulmonary NK cells in C...

2011
Anahid Jewett Han-Ching Tseng

Accumulated evidence indicates that cytotoxic function of immune effectors is largely suppressed in the tumor microenvironment by a number of distinct effectors and their secreted factors. The aims of this review are to provide a rationale and a potential mechanism for immunosuppression in cancer and to demonstrate the significance of such immunosuppression in cellular differentiation and progr...

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