نتایج جستجو برای: nitrones

تعداد نتایج: 453  

Journal: :Aging cell 2007
Richard A Miller David E Harrison Clinton M Astle Robert A Floyd Kevin Flurkey Kenneth L Hensley Martin A Javors Christiaan Leeuwenburgh James F Nelson Ennio Ongini Nancy L Nadon Huber R Warner Randy Strong

The National Institute on Aging's Interventions Testing Program (ITP) has developed a plan to evaluate agents that are considered plausible candidates for delaying rates of aging. Key features include: (i) use of genetically heterogeneous mice (a standardized four-way cross), (ii) replication at three test sites (the Jackson Laboratory, TJL; University of Michigan, UM; and University of Texas, ...

Journal: :Organic & biomolecular chemistry 2009
Shao-Feng Wu Xiao Zheng Yuan-Ping Ruan Pei-Qiang Huang

A flexible diastereoselective approach to trans-(3S)-hydroxyprolinol derivatives is described, which is based on the samarium diiodide-mediated reductive coupling of the chiral 1-pyrroline N-oxide (nitrone)(S)-10 with carbonyl compounds. The reductive hydroxyalkylation of nitrone 10 with ketones and aromatic aldehydes is highly diastereoselective in establishing the C-2 chiral center of the pyr...

Journal: :Angewandte Chemie 2003
Ian S Young Michael A Kerr

Cycloadditions are among the most trusted of chemical transformations available to the synthetic chemist. The predictability of the transition state based on steric and electronic considerations allows for the strategic construction of complex molecular assemblies. While the Diels–Alder reaction has received the most attention, 1,3-dipolar cycloadditions have also maintained a place of prominen...

2006
Michalis Papadakis Alastair M. Buchan

NXY-059 is a nitrone compound with free radical trapping properties that appears to be neuroprotective in some animal models of stroke.1,2 The publication this month of SAINT-I trial in the New England Journal of Medicine3 demonstrates a small but statistically significant improvement of the primary outcome by NXY-059 treatment. The authors observed reduced disability at 90 days as assessed by ...

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