Novel biomarker discovery plays a crucial role in providing more sensitive and specific disease detection. Unfortunately many low-abundance biomarkers that exist in biological fluids cannot be easily detected with mass spectrometry or immunoassays because they are present in very low concentration, are labile, and are often masked by high-abundance proteins such as albumin or immunoglobulin. Ba...

Polymer gels are regarded as a potential dosimeter for independent validation of absorbed doses in clinical radiotherapy. Several imaging modalities have been used to convert radiation-induced polymerization to absorbed doses from a macro-scale viewpoint. This study developed a novel dose conversion mechanism by texture analysis of scanning electron microscopy (SEM) images. The modified N-isopr...

Objective(s) In this study, a kind of pH sensitive composite membrane was prepared and drug permeation through it was investigated in terms of pH. Rationale of this study originated from the fact that a pH change which may be a result of a disease state in the body can trigger drug release. Materials and Methods  Here, a kind of pH sensitive composite membrane containing different nanoparticle ...

Abstract A new selective polymeric composite capped with crown ether was successfully synthesized using N -isopropyl acrylamide copolymerized acrylic acid paired Dibenzo-18-crown-6, P(NIPAm-Co-AA-DB 18C-6), by Gamma irradiation and ultrasonic homogenizer polymerization. Scanner electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering were used to chara...

Poly(N-isopropylacrylamide) (PNIPAM) is the premier example of a macromolecule that undergoes a hydrophobic collapse when heated above its lower critical solution temperature (LCST). Here we utilize dynamic light scattering, H-NMR, and steady-state and time-resolved UVRR measurements to determine the molecular mechanism of PNIPAM's hydrophobic collapse. Our steady-state results indicate that in...

The moisture uptake of several water-soluble polymers at different humidities was investigated with a thermal gravimetric analyzer equipped with a controlled humidity chamber. The water sorption of poly(acrylic acid) sodium salt, poly(ethylene glycol) and silica, which are known as super absorbers, were examined. In addition, various hydrophilic polymeric materials were selected according to th...

Glucose-responsive systems that can change their volumes or other properties in response to glucose concentration, show great potential as drug delivery carriers for controlled release of insulin for diabetes therapy or targeted delivery of anticancer drugs for cancer treatment. In this study, we report on a novel type of monodisperse phenylboronic acid (PBA)-based microcapsules for glucose-res...