An eye is the most precious and easily accessible organ of the body. It possesses easy route to local drug delivery and is a way to non-invasive clinical treatment of ocular diseases. Ocular delivery in spite of possessing various advantages has the limitation of poor bioavailability and low permeability across the cornea thus, limiting the efficacy of drugs. Therefore, various carrier systems ...

Abstract Extraction from the herbs was performed using Soxhlet method. Various formula synthesized for niosomes containing extracts through thin film synthesis technique, and most efficient formulation selected. Afterwards, physicochemical properties of niosomes, including size, polydispersity index (PDI), zeta potential, morphology, encapsulation efficacy (EE%), extract release rate, non-inter...

Carvedilol (CRV) is an antihypertensive drug with both alpha and beta receptor blocking activity used to preclude angina and cardiac arrhythmias. To overcome the low, variable oral bioavailability of CRV, niosomal formulations were prepared and characterized: plain niosomes (without bile salts), bile salt-enriched niosomes (bilosomes containing various percentages of sodium cholate or sodium ta...

In this investigation, curcumin niosomal nanoparticles were prepared via a simple, efficient and eco-friendly route, thin film hydration (TFH), in the presence of different mixture of the surfactants (tween 60 and span 60). Cholesterol ratio to surfactant, as effective factor, was altered to obtain the optimal nanoparticles. The size, zeta potential, size distribution, entrapment efficiency of ...