adenosine acts as neuromodulator in the brain, which its involvement in a wide range of brain processes and diseases has been studied, such as epilepsy, sleep, anxiety, panic disorder, alzheimer’s disease, parkinson’s disease and schizophrenia. adenosine receptors have been detected: a1r, a2ar (a2ar), a2br, and a3r. a1r and a2r inhibit camp production, while a2ar and a2br stimulate camp product...

Neurons in the primate striatum and the substantia nigra pars compacta change their firing patterns during sensory-motor learning. To study the consequences of nigrostriatal dopamine depletion for learning and memory of motor sequences, we used a neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), to deplete dopamine unilaterally in the striatum of macaque monkeys either before or ...

To describe a patient with drug-induced parkinsonism whose baseline dopamine transporter SPECT resulted abnormal, but whose dopaminergic neuronal density was normal. Background: In vivo imaging techniques investigating presynaptic nigrostriatal function using dopamine transporter (DAT) SPECT or 18F-Dopa PET are currently considered to reliably distinguish a degenerative parkinsonism from a iatr...