Exposure to chemical mixtures is more common than exposure to a single chemical. Skin is the largest tissue in the human body and is an important route of exposure to chemical mixtures. The aim of this study was to assess the effect of toluene, trichloroethylene (TCE) and phenol on the dermal bioavailability of nickel. All four compounds are prevalent in the environment, at industrial facilitie...

This study was performed to establish a convenient mouse model for the evaluation of nickel allergy. For sensitization, 0.2 g of nickel sulfate in petrolatum was applied 4 times every other day to the shaved dorsal skin. Seven days after the first application of the nickel sulfate salt sample, the antigen-specific metal allergy reaction was estimated based on the swelling response of the footpa...

The Sleeping Beauty problem (Elga, 2000; see also Piccione and Rubinstein, 1997) is a philosophical dilemma related to conditional probability. It may be succinctly described as follows. Sleeping Beauty is put to sleep, and a fair coin (say, a nickel) is tossed. If the nickel shows heads, then Beauty is interviewed on Monday only, while if the nickel shows tails, Beauty is interviewed on both M...

A new PVC membrane ion selective electrode which is highly selective towards Ni(II) ions was constructed using a Schiff base containing a binaphthyl moiety as the ionophore. The sensor exhibited a good Nernstian response for nickel ions over the concentration range 1.0x10(-1)-5.0x10(-6) M with a lower limit of detection of 1.3x10(-6) M. It has a fast response time and can be used for a period o...

There is increasing evidence that the nervous system has influence on the immune response. The effect of vasoactive intestinal peptide (VIP) and of serotonin and its antagonists on the challenge phase of allergic contact dermatitis in humans were tested. The substances were injected intracutaneously shortly before and 6 h after application of patch tests with nickel sulphate in nickel-allergic ...

To Investigate the role played by nickel co-ions in contributing to the stability of arsenic, fluorescence XAFS measurements at both arsenic K-edge and nickel K-edge, respectively, on amorphous arsenical nickel hydroxide, crystalline arsenical nickel hydroxide, and annabergite reference compounds have been carried out. The XAFS results indicate that the arsenic-bearing nickel hydroxides have a ...

OBJECTIVE We examined the pulmonary toxicity of nickel oxide nanoparticle agglomerates in the rat lung following an intratracheal instillation. METHODS The weighted average surface primary diameter of nickel oxide nanoparticles was 8.41 nm, and the count median diameter of nickel oxide nanoparticle agglomerates suspended in saline was 1.34 µm. Male Wistar rats were exposed to 1 mg (3.3 mg/kg)...

INTRODUCTION In spite of growing concern of routine mechanotherapy modalities in patients' health and recent regulations on nickel exposure, there has been no relevant meta-analysis. The aim of this study, therefore, was to investigate the effect of orthodontic therapy on the prevalence of nickel hypersensitivity and compare it with the prevalence in the general population. METHODS Several el...

Nickel nanoparticles have been synthesized using nickel nitrate, vegetable oil and sucrose. Ethanol has been used as a solvent since the heat of reaction shows the destabilization of nickel particles if water is present in the synthesis mixture. Nickel with fcc phase is obtained by reduction with sucrose followed by stabilization using vegetable oil. Nickel or possibly nickel carbide with hcp s...

Both nickel and cadmium compounds have been established as group I carcinogens for several decades. Despite over-whelming evidence of these compounds' carcinogenicity in humans, the specific underlying molecular mechanisms that govern metal induced cellular transformation remain unclear. In this study, we found that there were slightly different effects on decreased SLBP mRNA and protein as wel...