OBJECTIVE To investigate the effects on cardiovascular outcomes of drug interventions that increase high density lipoprotein levels. DESIGN Meta-analysis. STUDIES REVIEWED Therapeutic benefit of niacin, fibrates, and cholesteryl ester transfer protein (CETP) inhibitors on cardiovascular events (all cause mortality, coronary heart disease mortality, non-fatal myocardial infarction, and strok...

OBJECTIVE To investigate the effect of extended-release (ER) niacin on the metabolism of high-density lipoprotein (HDL) apolipoprotein A-I (apoA-I) in men with type 2 diabetes mellitus on a background of optimal statin therapy. APPROACH AND RESULTS Twelve men with type 2 diabetes mellitus were recruited for a randomized, crossover design trial. Patients were randomized to rosuvastatin or rosu...

Expecting to blush is a common source of social anxiety, and is associated with heightened perceptions of blushing and embarrassment. To assess whether sensory cues associated with heightened facial blood flow are an additional source of anxiety, the vasodilator niacin (100mg) or placebo was administered double-blind to 33 participants, and facial blood flow was investigated when they sang a ch...

The availability of deuterium-labeled nicotinic acid makes stable isotope dilution mass spectromerty (MS) coupled with liquid chromatography (LC) an attractive option for the determination of the water-soluble B-vitamin niacin in food samples. A method was developed based on acid digestion, solid-phase extraction with a strong cation exchange column, and reversed-phase chromatography with a C18...

This study investigated the effect of cooking method on nutritional composition and tenderness loin from Korean black goat crossbreed to apply meat senior-friendly foods. The samples loins were grilled medium (71°C) or boiled for 1 h, then utilized measurements proximate composition, energy, vitamin A, niacin, amino acid contents, texture profiles. contained lower (p<0.05) moisture content h...

The effect of feeding excess leucine on the urinary excretion of tryptcphan-niacin metabolites and nitrogen was studied in young and adult rats. Urinary excretion of quinolinic acid and N'methylnicotinamide was increased in both young and adult rats when L-leucine was added at 1.5% level to a 9% casein diet. Quinolinic acid excretion was more markedly affected in young rats, whereas N'-methylni...

The oral administration of neomycin or niacin as single-drug therapy can significantly lower total and low-density lipoprotein cholesterol concentrations in patients with type II hyperlipoproteinemia. However, in the majority of patients treated with one of these drugs as sole therapy plasma lipid and lipoprotein concentrations do not normalize. The effect of combined neomycin (2 g/day) and nia...

Fifty to sixty percent of patients with symptoms of chronic or recurrent discomfort concentrated at the upper abdomen can be diagnosed with what is termed functional dyspepsia or nonulcer dyspepsia (NUD). Other symptoms include belching, bloating, heartburn, nausea or vomiting. Insufficient stomach acid, a condition known as hypochlorhydria, might be responsible for the symptoms of NUD. Two cas...

BACKGROUND Extended-release niacin with laropiprant did not significantly reduce the risk of major vascular events and increased the risk of serious adverse events in Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE), but its net effects on health and healthcare costs are unknown. METHODS AND RESULTS 25 673 participants aged 50 to 80 years with...