نتایج جستجو برای: neutrophil activation

تعداد نتایج: 463084  

Journal: :American journal of physiology. Cell physiology 2002
Nadeem Fazal Walid M Al-Ghoul Megan J Schmidt Mashkoor A Choudhry Mohammed M Sayeed

We evaluated the dependency of neutrophil O production on PTK-Lyn and MAPK-ERK1/2 in rats after thermal injury. Activation of PTK-Lyn was assessed by immunoprecipitation. Phosphorylation of ERK1/2 was assessed by Western blot analysis. O production was measured by isoluminol-enhanced luminometry. Imaging technique was employed to measure neutrophil [Ca2+](i) in individual cells. Thermal injury ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Deborah S Goddard Kei-ichi Yamanaka Thomas S Kupper David A Jones

PURPOSE Cutaneous T-cell lymphoma (CTCL) is a spectrum of disease of unknown etiology defined by infiltrates of activated and malignant T cells in the skin. In working with blood from CTCL patients, we noticed frequent activation of neutrophils; therefore, we tested the hypothesis that neutrophils are activated in CTCL subjects compared with normal healthy controls. EXPERIMENTAL DESIGN Using ...

2016
Sinead M. Hurley Nataliya Lutay Bo Holmqvist Oonagh Shannon

Platelets contribute to inflammation however, the role of platelet activation during the pathophysiological response to invasive bacterial infection and sepsis is not clear. Herein, we have investigated platelet activation in a mouse model of invasive Streptococcus pyogenes infection at 5, 12, and 18 hours post infection and correlated this to parameters of infection. The platelet population in...

Journal: :Journal of cell science 2003
Sharon Dewitt Iraj Laffafian Maurice B Hallett

The temporal and spatial relationship between particle binding to the neutrophil by beta2 integrin (CR3), the Ca2+ elevation and subsequent oxidase activation has been unclear. This is because of the difficulty in studying the time course of individual phagocytic events in individual neutrophils. Here, we have used a micromanipulation technique to present C3bi-opsonised zymosan particles to the...

احمدی, جعفر , ندیمی, اسماعیل , نوق, حسین,

Background: Unstable angina is a critical phase of coronary heart disease with widely variable symptoms and prognosis. In recent years, the pathophysiological roles of platelet activation and inflammation in unstable angina have been elucidated. The main aim of this study was to evaluate the role of C-reactive protein (CRP) and neutrophil count as predictive factors for future events (in a six...

2016
Hisanori Domon Masataka Oda Tomoki Maekawa Kosuke Nagai Wataru Takeda Yutaka Terao

Streptococcus pneumoniae is a leading cause of bacterial pneumonia and is the principal cause of morbidity and mortality worldwide. Previous studies suggested that excessive activation of neutrophils results in the release of neutrophil elastase, which contributes to lung injury in severe pneumonia. Although both pneumococcal virulence factors and neutrophil elastase contribute to the developme...

Journal: :Blood 2003
Christopher D O'Brien Poay Lim Jing Sun Steven M Albelda

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), a tyrosine phosphoprotein highly expressed on endothelial cells and leukocytes, is an important component in the regulation of neutrophil transendothelial migration. Engagement of endothelial PECAM-1 activates tyrosine phosphorylation events and evokes prolonged calcium transients, while homophilic engagement of neutrophil PECAM-1 ac...

Journal: :journal of comprehensive pediatrics 0
nastaran khosravi pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iran hosein karimi pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) nasrin khalesi pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) rozita hoseini pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) mitra mehrazma pediatric transplantation and dialysis research center, iran university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences) niloofar khosravi ali-asghar children hospital, iran university of medical sciences, tehran, ir iran; ali-asghar children hospital, iran university of medical sciences, tehran, ir iran. tel: +98-2144297768سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)

conclusions sepsis enhances the production of plasma ngal in critically ill neonates. thus plasma ngal can help clinicians diagnose sepsis in critically ill neonates during early phases. results the ngal levels were significantly higher in septic neonates compared with non-septic neonates (102.9 ± 69.9 ng/ml versus 29.2 ± 13.3 ng/ml, p value = 0.0001). an optimal cut off-point of 48 ng/ml for s...

2011
Peter J. Cavnar Erwin Berthier David J. Beebe Anna Huttenlocher

Kostmann disease is an inherited severe congenital neutropenia syndrome associated with loss-of-function mutations in an adaptor protein HS1-associated protein X-1 (Hax1). How Hax1 regulates neutrophil function remains largely unknown. In this paper, we use ribonucleic acid interference to deplete Hax1 in the neutrophil-like cell line PLB-985 and identify Hax1 as a negative regulator of integri...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید