objective: this study was designed to investigate rbc indices and hba2 levels in parents of major beta-thalassemia patients to detect possible silent beta- thalassemia carriers and examine its potential impact on the premarital genetic counseling. materials and methods: this cross sectional study was performed at children medical center from 2004 to 2006. after genetic counseling and getting in...

chitosan-graft-polyethylenimine (chi-g-pei) copolymer has been used for theimprovement of low transfection efficiency of chitosan. the present study aims to test thepulmonary toxicity and efficiency of chi-g-pei as an aerosol gene carrier. mice were exposedto aerosol containing green-fluorescent protein (gfp)-polyethylenimine (pei) or gfp-chig-pei complexes for 30 min during the development of ...

hemophilia b is factor ix deficiency and is inherited as x-linked recessive disorder. the subject of carrier detection in hemophilias has received new impetus in the last several years. analysis of factor ix gene polymorphisms is considered the best approach for prenatal diagnosis and hemophilia b carrier detection, if the identification of the gene mutation is possible. allele frequencies of t...

The systemic clearance of many quinolone antibiotics is mainly via metabolism and urinary excretion; by contrast, biliary excretion is a major route of elimination for a new quinolone grepafloxacin (GPFX). Accordingly, we studied the hepatic uptake of GPFX because it is the first step in the drug's hepatobiliary transport. The hepatic uptake of GPFX in vivo after i.v. administration was found t...

Here, a simple, quick, Low cost and sensitive Potentiometric method is described for tramadol hydrochloride measurement using .PVC membrane electrode based on neutral ligand (E)-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazid. Besides, effect of various parameters like ionic additives, membrane solvent and pH on the Potentiometric response of the electrode are investigated. The best electrode p...

In present study, using Least Squares (LS) method, we determine the position smoothing in GPS single-frequency receiver by means of pseudo-range and carrier phase measurements. The application of pseudo-range or carrier phase measurements in GPS receiver positioning separately can lead to defects. By means of pseudo-range data, we have position with less precision and more distortion. By use of...

We report on the discovery of C7N- anion towards starless core TMC-1 and carbon-rich evolved star IRC+10216. used data QUIJOTE line survey found six lines in perfect harmonic frequency relation from J=27-26 up to J=32-31. The can be reproduced with a rotational constant distortion B=582.68490+/-0.00024 MHz D=4.01+/-0.13 Hz, respectively. standard deviation fit is 4 kHz. Towards IRC+10216, we id...

In industries, the demand for multi-phase Multi-Level Inverters (MLIs) increases as they have reduced switching loss, Common Mode Voltage (CMV) and voltage stress across switches. The Multi-Carrier PWM (MCPWM) Space Vector Modulation (SVM) techniques are predominantly used controlling inverter. This paper discusses various like PD, POD, APOD, IC, PSC, VFC SVM (OFV with Zero CMV) 5-phase NPC 3L ...

objective: the anti-cancer properties of curcumin, a poliphenol extract from the rhizome of curry, has been confirmed by many investigators. however, low levels of uptake, tissue distribution and rapid metabolism has limited its application as an anti-cancer drug. this study is aimed at increasing curcumin's water solubility due to a biodegradable, neutral and non-toxic micellar nano-carrier ca...

sol-gel and polymeric membrane electrodes, based on thiacalix[4]arene as a neutral carrier, weresuccessfully developed for the detection of vo2+ in aqueous solutions. the sol-gel and pvcmembrane electrodes exhibited linear response with nernstian slopes of 29.3 and 28.4 mv perdecade, respectively, within the vanadyl ion concentration ranges from 1.0 × 10-6 to 1.0 × 10-1mol dm-3 and from 1.0 × 1...