Neuronal activity results in a local increase in blood flow. This concept serves as the basis for functional MRI. Still, this approach remains indirect and may fail in situations interfering with the neurovascular coupling mechanisms (drugs, anesthesia). Here we establish that water molecular diffusion is directly modulated by underlying neuronal activity using a rat forepaw stimulation model u...

Nerves and vessels often run parallel to one another, a phenomenon that reflects their functional interdependency. Previous studies have suggested that neurovascular congruency in planar tissues such as skin is established through a "one-patterns-the-other" model, in which either the nervous system or the vascular system precedes developmentally and then instructs the other system to form using...

Neurovascular coupling is extensively studied in brain. However, much less is known about the neurovascular coupling in retina. Recently, we have observed that electrical field stimulation (EFS) of bovine retinal arteries surrounded by adherent retinal tissue elicits a rapid and reversible vasorelaxation. This can be due to the presence of retinal tissue. To confirm this hypothesis, we repeated...

Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance of healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair neurovascular coupling, likely contributing to age-related decline of higher cortical functions. There is increasing evidence showing that mitoch...

Although nervous and vascular systems are functionally different, they usually share similar mechanisms for function maintenance. Neurovascular dysfunction has became the pathogenesis of several vascular and nervous disorders. Here we show that long non-coding RNA-MIAT is aberrantly expressed under neurovascular dysfunction condition. MIAT is shown as a regulator of vascular dysfunction, includ...

The vascular and the nervous system are responsible for oxygen, nutrient, and information transfer and thereby constitute highly important communication systems in higher organisms. These functional similarities are reflected at the anatomical, cellular, and molecular levels, where common developmental principles and mutual crosstalks have evolved to coordinate their action. This resemblance of...

Introduction. Occipitocervical (OC) fusion is a method for fixation of the OC junction when there instability that segment. Arnold Chiari malformation congenital disorder where cerebellar tonsils descend through foramen magnum, which can lead to corticomedullar compression and formation syrinx. While treating this condition, purpose decompression, magnum expanded, potentially harm stability jun...

Prostate cancer is the most common amongst men, and one of its treatments in localized stage radical prostatectomy (RP). This technique achieves a high success rate regarding oncological results, but main drawbacks are sexual disorders, especially erectile dysfunction, ranging from 14-90% cases. Therefore, surgery advancements last decade have been focused on minimizing impact patient’s functio...

Neurovascular research has made significant strides toward understanding how the brain neurovascular unit accomplishes rapid and spatial increases in blood flow following neuronal activation. Among the experimental models used, the in vitro brain slice preparation provides unique information revealing the potential signals and cellular mechanisms involved in functional hyperemia. The most cruci...