نتایج جستجو برای: neuronal excitability

تعداد نتایج: 130346  

Journal: :Human brain mapping 2015
Kiyohide Usami Riki Matsumoto Katsuya Kobayashi Takefumi Hitomi Akihiro Shimotake Takayuki Kikuchi Masao Matsuhashi Takeharu Kunieda Nobuhiro Mikuni Susumu Miyamoto Hidenao Fukuyama Ryosuke Takahashi Akio Ikeda

Sleep-induced changes in human brain connectivity/excitability and their physiologic basis remain unclear, especially in the frontal lobe. We investigated sleep-induced connectivity and excitability changes in 11 patients who underwent chronic implantation of subdural electrodes for epilepsy surgery. Single-pulse electrical stimuli were directly injected to a part of the cortices, and cortico-c...

Journal: :Brazilian Journal of Medical and Biological Research 2013

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
D C Johns R Marx R E Mains B O'Rourke E Marbán

Graded, reversible suppression of neuronal excitability represents a logical goal of therapy for epilepsy and intractable pain. To achieve such suppression, we have developed the means to transfer "electrical silencing" genes into neurons with sensitive control of transgene expression. An ecdysone-inducible promoter drives the expression of inwardly rectifying potassium channels in polycistroni...

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