Iris melanosis is an unusual condition characterised by the presence of minute, discrete, pigmented elevations arising from the anterior surface of the iris. We encountered two unrelated Mexican families in which all children, but no parent, had varying degrees of the condition bilaterally. Some family members also gave findings suggestive of ocular hypertension. No family member had any other ...

6. Mitty RD, Wolfe GR, Cosman M. Initial description of gastric melanosis in a laxative-abusing patient. Am J Gastro. 1997;92:707--8. 7. Lin HJ, Tsay SH, Chiang H. Pseudomelanosis duodeni. Case report and review of literature. J Clin Gastroenterol. 1988;10:155--9. 8. Alberti JE, Bodor J, Torres AD. Primary malignant melanoma of the esophagus associated with melanosis of the esophagus and stomac...

6. Mitty RD, Wolfe GR, Cosman M. Initial description of gastric melanosis in a laxative-abusing patient. Am J Gastro. 1997;92:707--8. 7. Lin HJ, Tsay SH, Chiang H. Pseudomelanosis duodeni. Case report and review of literature. J Clin Gastroenterol. 1988;10:155--9. 8. Alberti JE, Bodor J, Torres AD. Primary malignant melanoma of the esophagus associated with melanosis of the esophagus and stomac...

A 58-year-old man with a history of hemorrhoidectomy and chronic constipation presented for routine surveillance colonoscopy. He took an over-the-counter herbal laxative containing senna for constipation. The rectal mucosa showed a brownish discoloration in a moire pattern, characteristic of melanosis coli. Advancing beyond the rectum, the full circumference of colonic mucosa turned jet black i...

Congenital diffuse Melanosis is one of the rarest clinical manifestations of hereditary universal Melanosis and only few cases have been reported all over the world. The presented case is a 54-year-old man who presented to us complaining of erythematous annular lesions on his face and neck since 8 months ago. Diffuse pigmentation of his skin took our attention. According to the patient, d...

esophageal melanocytosis is a rare and benign condition, characterized by melanocytic proliferation of the esophageal squamous epithelium with heavy melanin deposition. the etiology and pathogenesis has not been exactly known but it seems to be a chronic stimulus such as gastroesophageal reflux. this condition is very rare and about 35 cases have been reported so far, most of which have been fr...