OBJECTIVE To assess optical coherence tomography in differentiating optic disc edema (ODE) due to papilledema and other optic neuropathies from optic nerve head drusen (ONHD). METHODS Optical coherence tomographic images from 60 subjects (20 with ODE, 20 with ONHD, and 20 control subjects) were assessed qualitatively and quantitatively. Qualitative criteria for ODE included an elevated optic ...

BACKGROUND Though intra-epidermal nerve fiber density (IENFD) is considered the gold standard for diagnosis of small fiber sensory neuropathy (SFSN), we aimed to determine if novel threshold values derived from standard tests of small or large fiber function could serve as diagnostic alternatives. METHODS Seventy-four consecutive patients with painful polyneuropathy and normal nerve conductio...

Small-fiber neuropathy is a peripheral nerve disease that most commonly presents in middle-aged and older people, who develop burning pain in their feet. Although it can be caused by disorders of metabolism such as diabetes, chronic infections (such as with human immunodeficiency virus), genetic abnormalities, toxicity from various drugs, and autoimmune diseases, the cause often remains a myste...

Ophthalmoscopic scrutiny of the nerve fiber layer was first advocated by Hoyt, over 30 years ago. In the following years, the importance of localized defects of the retinal nerve fiber layer (NFL) for the diagnosis of glaucoma has been demonstrated in many studies. The evaluation of the NFL, though relatively difficult and subjective, has become routine in the common ophthalmic examination. We ...

RESEARCH DESIGN AND METHODS — Endothelium-dependent and C fiber– mediated SkBF, sensory symptoms, neurological deficits, nerve fiber morphometry, quantitative sensory and autonomic function testing, nerve conduction studies, quality of life (using the Norfolk Quality-of-Life Questionnaire for Diabetic Neuropathy [QOL-DN]), and adverse events were evaluated for 20 placeboand 20 ruboxistaurin-tre...

background: endometriosis is a common, benign, oestrogen-dependent, chronic gynaecological disorder associated with pelvic pain and infertility. some researchers have identified nerve fibers in endometriotic lesions in women with endometriosis. mesenchymal stem cells (mscs) have attracted interest for their possible use for both cell and gene therapies because of their capacity for self-renewal...