نتایج جستجو برای: nerve degeneration
تعداد نتایج: 211971 فیلتر نتایج به سال:
Therapies that might delay degeneration of synapses offer an appealing strategy for treatment of neurodegenerative diseases, including Alzheimer’s disease and related dementias, prion diseases, schizophrenia and amyotrophic lateral sclerosis. Analysis of mouse mutants provides one possible avenue towards identifying relevantmechanisms.Here, we used quantitative and serial section electronmicros...
NEUMANN in 1868 proposed the idea that severed peripheral nerve degenerates centrifugally; i.e., the degenerative processes start at the cut end and progress slowly towards the periphery. This view, opposing the conception of simultaneous degeneration advanced by Lent in 1856, started a controversy as yet unsettled. Most of the arguments on both sides have been based on histological evidence-on...
Nociceptive nerves innervate the skin and play an important role in the generation of neuropathic pain. However, it remains elusive whether and how nociceptive nerve terminals degenerate in neuropathic pain conditions. To address this issue, we investigated cutaneous innervation in a model of painful mononeuropathy, the chronic constriction injury (CCI). The hind paws of rats were immunocytoche...
We cut the optic nerve at the orbital apex in squirrel monkeys to study the descending degeneration of optic nerve axons and their ganglion cell bodies. We could not detect progressive disintegration of the axon from the site of injury back to the cell body. Instead, the entire length of individual axons seemed to degenerate simultaneously as early as 3 weeks and as late as 6 weeks after injury...
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