Nevzat Karabulut Life is continuously confronting us with new issues and sometimes breaking our routine. One case in point is the curious way radiologists’ knowledge about the benefits and risks of gadolinium-based contrast agents (GBCAs) continues to evolve. Significantly improving detection and characterization of lesions in a broad spectrum of diseases, GBCAs have become integral aides to ma...

BACKGROUND AND OBJECTIVES During the past decade, nephrogenic systemic fibrosis (NSF) has been reported in patients who have severe renal impairment and have been exposed to a gadolinium (Gd)-based contrast agent during magnetic resonance imaging (MRI). As a result of positive reporting bias, many suitable patients with chronic kidney disease (CKD) are being denied a highly important form of in...

BACKGROUND Nephrogenic systemic fibrosis (NSF) is a systemic disorder of patients with severe renal insufficiency who have received gadolinium (Gd)-based magnetic resonance contrast agents (GBCAs). The causative association with Gd exposure was strengthened by the demonstration of Gd in various tissues of NSF patients, predominantly at the bulk chemical level. The distribution of Gd at the hist...

Objective: The objective of this study was to assess the risk of gadoxetate disodium in liver imaging for the development of nephrogenic systemic fibrosis (NSF) in patients with moderate to severe renal impairment. Materials andMethods:Weperformed a prospective,multicenter, nonrandomized, open-label phase 4 study in 35 centers from May 2009 to July 2013. The study population consisted of patien...

Choi JH et al. Vitamin E improves microsomal phospholipase A2 activity and the arachidonic acid cascade in kidney of diabetic rats. Gadolinium-based contrast agents, erythropoietin and nephrogenic systemic fibrosis in patients with end-stage renal failure Sir, Nephrogenic systemic fibrosis (NSF) is a rare and debili-tating disorder, which affects patients with kidney failure. An association wit...

INTRODUCTION Nephrogenic adenomas are generally considered to be benign lesions, but there remains a risk for malignant transformation. Patients with immunosuppression in particular appear to be at a higher risk of malignant disease. We report a case of post-traumatic nephrogenic adenoma in a young patient without immunosuppression, which transformed into an adenocarcinoma of the bladder. CAS...

BACKGROUND.: In 2006, nephrologists in Denmark unexpectedly identified chronic kidney disease (CKD) patients with a new syndrome, nephrogenic systemic fibrosis (NSF). Subsequently, 1603 NSF patients were reported to the Food and Drug Administration. Sixty hospitals in the USA account for 93% of these cases, and two hospitals in Denmark account for 4% of these reports. We review Denmark's identi...

BACKGROUND The high incidence of renal insufficiency in patients with Peripheral Arterial Disease raises the concern for nephrogenic systemic fibrosis (NSF) with respect to contrast enhanced MRA. The risk of NSF is eliminated with non-contrast enhanced magnetic resonance angiography. The purpose of the current study is to compare image quality and diagnostic performance of non-contrast enhanced...

Peripheral vascular disease (PVD) has an age-adjusted prevalence of 12% in the United States, causes significant morbidity and is associated with excess cardiovascular mortality. Contrastenhanced magnetic resonance angiography (CE-MRA) often substitutes for the more invasive ―gold standard‖ procedure of digital subtraction angiography (DSA). Given the frequency of renal functional impairment in...