Within the group of the chronic rheumatic diseases, rheumatoid arthritis and rheumatoid spondylitis undoubtedly constitute the most important syndromes from the medical standpoint, not only because of their symptomatology and evolution, but also because their aetiological agents are unknown and because they are, therefore, a difficult and complex therapeutic problem. No wonder, therefore, there...

Exogenous stress like tissue damage and pathogen invasion during surgical trauma could lead to a peripheral inflammatory response and induce neuroinflammation, which can result in postoperative cognitive dysfunction (POCD). The cholinergic anti-inflammatory pathway is a neurohumoral mechanism that plays a prominent role by suppressing the inflammatory response. Treatments with acetylcholinester...

Relief of pain during surgery is the main aim of anesthesia. Any expertise acquired in this field should be extended into post operative period. Many options are available for the treatment of post-operative pain, including systemic analgesics (i.e., opioid and non opioid); and regional techniques. In this study opioid analgesic fentanyl and neostigmine which were injected in intrathecal space ...

neostigmine), reverses neuromuscular blockade rapidly and effectively by encapsulating free circulating steroidal neuromuscular blocking agents (e.g., rocuronium) directly [1]. Moreover, sugammadex does not have muscarinic properties, whereas neostigmine has significant adverse muscarinic effects. Therefore, sugammadex is used in many countries as a new neuromuscular reversal agent to antagoniz...

Background and aims: Use of neostigmine to reverse the non-depoloarizing neuromuscular block at end surgery is a standard practice. Reversal with based on body weight still commonly followed. However, may affect adversely if used empirically in absence residual blockade. This study compares empirical technique reversal using dose adjusted train-of-four (TOF) response. Methods: prospective, doub...

The effects of microinjections of cholinergic agents into the substantia nigra pars compacta on dopamine (DA) efflux in the anterior dorsomedial striatum of urethane-anesthetized rats were investigated using in vivo chronoamperometry and intracerebral microdialysis techniques. A dose-dependent augmentation of DA efflux as evidenced by increases in the chronoamperometric signals was observed in ...

We have examined spontaneous and neostigmine-induced recovery after an initial dose of Org 9487 1.5 mg kg-1 followed by three repeat doses of Org 9487, a 30-min infusion of Org 9487 or two incremental doses of rocuronium. Mean clinical duration after incremental doses of Org 9487 0.5 mg kg-1 increased from 12.3 (SD 3.4) min to 14.0 (4.0) and 15.9 (5.9) min (P < 0.01), and after rocuronium from ...