Starting first from Paget's "seed and soil" to the latest hypothesis about metastatic process involving the concept of a premetastatic niche, a large amount of data suggested the idea that metastatization is a multistep coordinated process with a high degree of efficiency. A specific subpopulation of cells with tumor-initiating and migratory capacity can selectively migrate toward sites that a...

Morphological, immunologic, and functional properties of peripheral blood cells from two patients with chronic proliferations of granular lymphocytes are described. Cells from both patients showed a heterogeneous pattern from both a morphological and immunologic standpoint, indicating a polyclonal, rather than a monoclonal, expansion of these cells. In fact, both large and small-to-medium-sized...

Background: Ovary is the commonest site of neoplastic and non-neoplastic lesion, can present in childhood to postmenopausal age group accounts for most prevalent cause hospital admissions. Aims & Objectives: (1) To know about various histopathological types ovarian lesions presented diagnosed. (2) study incidence with respect patient’s age. (3) frequency terms or neoplastic, benign malignant, u...

Leucoerythroblastosis was considered as a circulating expression of haematological and non-haematological malignancies. However many benign conditions are also associated with leucoerythroblastosis such hemolytic anaemia, marked infections congestive cardiac failure, etc. So the study performed to determine various causes leucoerythroblastic blood picture on bone marrow examination. The current...

Disease of the ovary are a significant cause of morbidity and mortality amongst Zimbabwean women. There is however, scanty data regarding the types and extent of these conditions. A retrospective review of histologically diagnosed ovarian disease was carried out in order to determine the types, prevalence and age distribution of ovarian pathology seen in Harare over a 22 month period. Pathologi...