objectives colloidal drug delivery system, solid lipid nanoparticles (slns), helps to increase the solubility of the drug and its oral bioavailability. methods tamoxifen (tam) as a nonsteroidalantiestrogen drug was formulated in sln and an in vitro study was conducted to determine the cytotoxicity effect of tam-loaded slns on human breast cancer cell lines mcf-7 (estrogen receptor-positive) and...

kaposiform hemangioendothelioma (khe) appears as a single lesion at birth or early infancy in an equal sex ratio. a rare aggressive vascular proliferation has been recognized as a separate entity from other childhood vascular neoplasm. a 3-year-old iranian boy with a rapidly enlarging mass in his (posterior aspect of skull at the midline) skull was present here. physical examination revealed a ...

background and objectives: having spiritual health is an effective factor in recovery of cancer patients. therefore, due to the importance of spiritual health in outcome of cancer patients, this study aimed at assessing spiritual health and its related factors in cancer patients. methods: this descriptive-correlational study was carried out on 150 cancer patients who were at least 18 years old ...

Epithelial cell adhesion molecule 1 (EpCAM) is an epithelial membrane glycoprotein, often used as a surrogate pan-epithelial marker. To compare the expression patterns of EpCAM and pankeratin antibody (CKpan), gold standard detection, tissue microarrays containing 11,053 samples from 101 different tumor types were analysed by immunohistochemistry. staining was detectable in 99 (82.5%) 120 tumou...

BACKGROUND Uro-oncological neoplasms have both a high incidence and mortality rate and are therefore a major public health problem. The aim of this study was to evaluate research activity in uro-oncology over the last decade. METHODS We searched MEDLINE and ClinicalTrials.gov systematically for studies on prostatic, urinary bladder, kidney, and testicular neoplasms. The increase in newly publ...

Most DNA methylation studies in classic Philadelphia-negative myeloproliferative neoplasms have been performed on a gene-by-gene basis. Therefore, a more comprehensive methylation profiling is needed to study the implications of this epigenetic marker in myeloproliferative neoplasms. Here, we have analyzed 71 chronic (24 polycythemia vera, 23 essential thrombocythemia and 24 primary myelofibros...

BACKGROUND Cystic neoplasms comprise 1-10% of all pancreatic neoplasms. Most authors recommend resection due to the difficulties in differentiating benign from malignant tumors prior to operation. We performed an analysis on the radical surgical handling of patients with cystic neoplasms of the pancreas. PATIENTS AND METHODS We analyzed data of all patients with pancreatic neoplasms who were ...

INTRODUCTION Malignant disorders have been linked to the HIV epidemic from its onset. Implementation of highly active antiretroviral therapy (HAART) has resulted in a dramatic reduction in the HIV/AIDS morbidity and mortality. The present study evaluates the neoplasm prevalence before and after the implementation of HAART. METHODS A cross-sectional study was conducted in 171 HIV-infected adul...

INTRODUCTION The analysis of premature deaths measured with years of life lost between the studied and referential populations helps to emphasize the social and economic aspect of a loss caused by deaths due to malignant neoplasms. The aim of the study was to analyze years of life lost by inhabitants of the Lodz province due to malignant neoplasms. MATERIAL AND METHODS The study material incl...

CONTEXT Autopsy often reveals new diagnoses of malignant neoplasms, but as technological advances to improve diagnosis during life have improved, autopsy rates have declined dramatically. OBJECTIVE To determine if there is still a high discordance rate between clinical and autopsy diagnoses of malignant neoplasms despite increasing technological advances in diagnostic methods. DESIGN AND SE...