OBJECTIVE To outline the pharmacodynamics, efficacy and safety of besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis. QUALITY OF EVIDENCE MEDLINE database was searched to review recent pharmacodynamic and clinical studies evaluating besifloxacin and comparing besifloxacin to other topical antibiotics for ophthalmic use. Findings were limited to full-text arti...

Foreign bodies are usually detected at the first visit. However, they may be overlooked sometimes, especially in children, and may cause some clinical conditions including unilateral relapsing conjunctivitis. A five-year-old girl was presented to the emergency clinic of our hospital with epiphora, purulent discharge, eyelid swelling, and a foreign body feeling in her right eye. The symptoms had...

Purpose To investigate the drug release profiles of a tacrolimus-loaded poly(D,L-lactide-co-ε-caprolactone) (PLC) microfilm, and to evaluate its efficacy on the treatment of allergic conjunctivitis using a mouse model. Methods The in vitro and in vivo drug release profiles were first characterized. Balb/c mice were immunized with short ragweed (SRW) injection followed by re-challenges with to...

PURPOSE To describe the demographics, characteristics, and treatment of giant fornix syndrome, a rare cause of chronic purulent conjunctivitis in the elderly. METHODS Retrospective chart review of five patients with giant fornix syndrome evaluated by the Cornea Service, Oculoplastics and Orbital Surgery Service and the Department of Pathology at the Wills Eye Institute. RESULTS The median a...

AUREO0MYCIN has now become established as an important and powerful antibiotic and has proved itself effective in several ophthalmological infections which failed to respond to other treatment. A preliminary' report has already been made from this clinic on the use of this drug in ophthalmology (Duke-Elder and others, 1950). The present communication describes our further experiences with this ...

Introduction: Vitiligo is a chronic acquired disorder presenting with depigmented macules and patches. The response to treatment is variable as no single therapy produces predictably good results. Needling with topical 5% 5 fluorouracil in vitiligo has been found to be promising, effective and safe modality of treatment. Materials and methods: Three patients with stable vitiligo were on medical...

A monoclonal antibody that recognizes the carboxyl terminus of substance P was used to localize tachykinin-like immunoreactivity in neurons of area 17 of the adult monkey cerebral cortex. Tachykinin immunostaining was examined in normal monkeys, in monkeys receiving monocular injections of the sodium channel blocker TTX for 10 or 15 d, and in monkeys from which the crystalline lens of one eye h...

PURPOSE To compare the clinical and bacteriological effects of fucidic acid (Fucithalmic: 1.0%) and chloramphenicol (Minims(R): 0.5%) eye drops in neonates with a clinical diagnosis of acute conjunctivitis of suspected bacterial origin. METHODS A TOTAL OF 456 N: ewborns with gestational age > 32 weeks with acute conjunctivitis of suspected bacterial origin acquired within the first 28 days of...

A full-term female neonate developed focal motor seizures at 1 hour of life, followed by paroxysmal nonepileptic abnormal eye–head movements on day 5 (video 1). CSF revealed mild hypoglycorrhachia, borderline low CSF:serum glucose, and pyridoxal-5′-phosphate (P5P). Genetic testing showed compound heterozygous mutations in the pyridoxamine 5′-phosphate oxidase ( PNPO ) gene consistent with P5P-d...