Conventional kinesin, a dimeric molecular motor, uses ATP-dependent conformational changes to move unidirectionally along a row of tubulin subunits on a microtubule. Two models have been advanced for the major structural change underlying kinesin motility: the first involves an unzippering/zippering of a small peptide (neck linker) from the motor catalytic core and the second proposes an unwind...

BACKGROUND Clinical detection of anatomic narrowing of the upper airway may facilitate early recognition of obstructive sleep apnoea (OSA). The aim of this study was to investigate whether anthropometric measurement can be used to predict OSA. MATERIALS AND METHODS One hundred forty-seven subject were included from those patients who were referred to our sleep laboratory with suspected sleep ...

OBJECTIVES/HYPOTHESIS Selective reinnervation of the posterior cricoarytenoid muscle with a single phrenic nerve rootlet has been shown to restore physiologic motion in animal models. However, clinical translation of this work is challenged by the limited knowledge of the cervical anatomy of the phrenic nerve. STUDY DESIGN Prospective collaborative study. METHODS Dissection of 111 cadaveric...

OBJECTIVE To determine if age alone is a prognostic indicator of surgical outcomes for major head and neck procedures. DESIGN Retrospective cohort study over a 4-year period. SETTING Academic referral center, institutional practice, hospitalized care. PATIENTS Included in this study were patients who had undergone ablative, reconstructive, and other major surgical procedures of the head a...

OBJECTIVES To describe the topography of the superior laryngeal nerve (SLN) and to evaluate the influence of gender, ethnicity, side of the neck, and individual height on the topography of the SLN. DESIGN Anatomical study of human cadavers. SUBJECTS Fifty fresh human cadavers (19 female subjects and 31 male subjects; age range, 22-89 years; mean age, 61 years) were randomly selected for thi...

PURPOSE Cone shape neck is regarded as non-instruction for use (IFU) in most commercial stent graft. However, in real practice, liberal application of endovascular aneurysm repair (EVAR) for outside of IFU happens. We investigate non-adherence to conical neck anatomy in terms of early aneurysmal exclusion results. MATERIALS AND METHODS From January 2010 to December 2013, 105 patients with abd...