Aspartame is a widely used artificial sweetener that has been linked to pediatric and adolescent migraines. Upon ingestion, aspartame is broken, converted, and oxidized into formaldehyde in various tissues. We present the first case series of aspartame-associated migraines related to clinically relevant positive reactions to formaldehyde on patch testing.

Cyclamate is widely used as intense sweetener in the European Union. The absence of a maximum limit for the use of cyclamate in tabletop sweeteners and the growing demand for this type of product highlights the importance of developing robust analytical methods for the determination of its content to understand if the consumption of tabletop sweeteners can have a negative impact on human health...

Background: Stevia is a natural, non-caloric sweetener with antimicrobial, antioxidant and anti-cariogenic properties. Aim was to assess compare the effect of 4.7% stevia solution, sucrose solution distilled water mouth rinsing on salivary pH. Methods: Randomized controlled trial latin square design followed involving 15 female participants aged 20-23 years. Participants were randomly allocated...

The monofloral avocado honey (AH), characterized by its dark amber color, contains a higher level of bioactive compounds than the multi-floral honey; these characteristics qualify it as possible sweetener alternative for domestic use. Therefore, purpose present study was to assess effect consumption (25 g/day) on anthropometric and biochemical parameters in healthy subjects 4-weeks. Thirteen (c...