In this study we evaluated the role of thromboxane in causing allergen-induced early and late asthmatic responses and airway hyperresponsiveness in asthmatic subjects. Twelve atopic subjects with stable asthma and documented early and late asthmatic responses to an inhaled allergen were treated with placebo or CGS 13080, a specific thromboxane synthetase inhibitor, given orally (200 mg four tim...

gen tolerance. In this regard, animal models represent very helpful tools to analyze the immune effects of AIT in more detail since they allow investigators to focus on certain aspects when evaluating the immune mechanisms of tolerance induction, and can thus close a gap between in vitro analysis and immunological studies in humans [10] . A variety of mouse models have been developed to study t...

gen tolerance. In this regard, animal models represent very helpful tools to analyze the immune effects of AIT in more detail since they allow investigators to focus on certain aspects when evaluating the immune mechanisms of tolerance induction, and can thus close a gap between in vitro analysis and immunological studies in humans [10] . A variety of mouse models have been developed to study t...

Allergen exposure plays a major role in the development of sensitization, inflammation and symptomatic asthma. The development of new means of detecting allergens has enabled the evaluation of the effect of a reduction in allergen exposure to be better assessed. In order to prevent allergen exposure it is necessary to determine the allergen sources and reservoirs to which avoidance measures sho...

gen tolerance. In this regard, animal models represent very helpful tools to analyze the immune effects of AIT in more detail since they allow investigators to focus on certain aspects when evaluating the immune mechanisms of tolerance induction, and can thus close a gap between in vitro analysis and immunological studies in humans [10] . A variety of mouse models have been developed to study t...

BACKGROUND Conflicting results have been reported in studies of predictive factors for airway responsiveness to allergens during bronchial challenges. OBJECTIVE The aim of this study was to assess determinants of airway responsiveness to 3 different allergens during standardized bronchial challenges. METHODS Data were collected from asthmatic patients who participated in allergen challenge ...

Purpose: To develop chitosan/alginate microparticles for the mucosal delivery of allergen from dust mite (Dermatophagoides pteronyssinus). Methods: Chitosan/alginate microparticles were prepared by ionotropic gelation. The effects of polymer content, crosslinking agent, and preparation method on the physicochemical characteristics of the microparticles as well as their in vitro cytotoxicity wer...