Local immunity seems to play a major role in the resistance to infection by rhinoviruses (10). Since foot-and-mouth disease virus (FMDV) shows many of the features of a rhinovirus (8), local immunity in cattle could provide resistance against the disease (7), and it would be possible to appraise it by searching for neutralizing antibodies in nasal secretions. The present work is an investigatio...

Mice were successfully immunized against the intestinal nematode Trichinella spiralis by intranasal administration of a 30-mer peptide antigen with cholera toxin B. Immunized mice developed antigen-specific serum immunoglobulin G1, intestinal immunoglobulin A, and a type 2-biased cytokine response. Intranasal immunization therefore generates the Th2-mediated responses required for immunity agai...

To increase the systemic and mucosal immune responses against the nasally administered tetanus toxoid, liposomes as a drug delivery system and CpG-ODN as an adjuvant were evaluated. Rabbits were nasally immunized with entrapped tetanus toxoid (TT) and CpG-ODN in neutral liposomes and systemic and mucosal immune responses were determined. Liposomes containing TT and CpG-ODN were prepared by dehy...

Local immunity seems to play a major role in the resistance to infection by rhinoviruses (10). Since foot-and-mouth disease virus (FMDV) shows many of the features of a rhinovirus (8), local immunity in cattle could provide resistance against the disease (7), and it would be possible to appraise it by searching for neutralizing antibodies in nasal secretions. The present work is an investigatio...

Rotavirus is the major cause of diarrhea among young infants in both humans and animals. Immune protection of newborns by vaccination is difficult to achieve since there is not enough time to mount an immune response before exposure to the virus. We have designed a vaccination strategy mediating transfer of neutralizing antibodies from the mother to the offspring during pregnancy and/or lactati...

  Abstract:   Background: The most important and complex phenomenon of respiratory function of the nose is related to different nasal anatomy. The differences in facial anatomic structure between different races may also be reflected in nasal resistance and airflow. Caucasians has different facial anatomic structure which is the reflection of intranasal resistance or consequence of airflow. The...

Introduction. Streptococcus pneumoniae is the most common pathogen causing respiratory tract infections and invasive infections. In 2012 and 2013 we observed an increased incidence of drug-resistant SP in patients treated in Pediatric Hospital of Warsaw Medical University. Aim. To evaluate the pneumococcal infections and the susceptibility to antibiotics. To examine the correlation between the ...

Zonula occludens toxin (Zot) is produced by toxigenic strains of Vibrio cholerae and has the ability to reversibly alter intestinal epithelial tight junctions, allowing the passage of macromolecules through the mucosal barrier. In the present study, we investigated whether Zot could be exploited to deliver soluble antigens through the nasal mucosa for the induction of antigen-specific systemic ...

Efficient induction of mucosal immunity usually employs nasal or oral vaccination while parenteral immunization generally is ineffective at generating mucosal immune responses. This relates to the unique ability of resident mucosal dendritic cells (DC) to induce IgA switching and to imprint mucosa-specific homing receptors on lymphocytes. Based on the well-established plasticity of the DC syste...

Pathogen-specific antibody plays an important role in protection against pneumococcal carriage and infections. However, neonates and infants exhibit impaired innate and adaptive immune responses, which result in their high susceptibility to pneumococci. To protect neonates and infants against pneumococcal infection it is important to elicit specific protective immune responses at very young age...