SIR,-The role of altered colonic detoxification mechanisms in various pathophysiological conditions including ulcerative colitis and carcinogenesis cannot be overemphasised. 2 We have thus read with great interest the recent report of Ramakrishna et al about sulphation as a mechanism ofphenolic compound inactivation in human colonocytes (Gut 1991; 32: 46-9). Though the work provides valuable ne...

A major problem in cancer chemotherapy is the lack of selective toxicity of many commonly used anti-cancer agents towards tumour tissue compared to normal tissue.1 This is due primarily to the fact that many of these drugs, such as the alkylating agents, attack rapidly dividing tissues of the host as well as the tumour. Another area of concern is the refractory nature of many solid tumours to e...

In the title compound, 2C(10)H(7)BrO·C(4)H(10)N(2), the piperazine (pip) mol-ecule displays a chair conformation and is linked to two mol-ecules of 6-bromo-2-naphthol (bno) via O-H⋯N hydrogen bonds. Weak N-H⋯O hydrogen bonds from pip to bno mol-ecules result in chains propagating in [100]. The chains inter-act via C-H⋯π inter-actions.

A stimulated mass enhancement strategy based on enormous biocatalytic precipitation of 4-chloro-1-naphthol using magnetic bead-supported horseradish peroxidase and glucose oxidase bienzymes was developed for the highly sensitive detection of interleukin-6 in serum using a quartz crystal microbalance technique.

We developed a chiral 1,1'-bi-2-naphthol-bridged imidazole dimer possessing 100 μs fast photochromism and high fatigue resistance. It offers great opportunities for the practical applications to fast photoresponsive chiral dopants, invisible security materials and optical trigger molecules to induce the dynamic structural changes in biological matters.

Chiral gold(i) phosphite complexes are readily prepared modularly from 3,3'-bis(triphenylsilyl)-1,1'-bi-2-naphthol. These chiral gold(i) phosphite complexes are very reactive precatalysts for the [4+2] cycloaddition of aryl-substituted 1,6-enynes with enantiomeric ratios ranging from 86 : 14 up to 94 : 6.

The kinetics of excited-state proton transfer to solvent from the strong photoacid 5-cyano-2-naphthol exhibits two different power-law asymptotic tails for acid and base, arising from competition between reversible and irreversible geminate reprotonation. We show that the data are in quantitative agreement with a recently developed theory for this diffusion-influenced reaction. q 2000 Elsevier ...

A sum-frequency generation (SFG) microscope that is sensitive toward molecular chirality was demonstrated for the first time. Optically active images of chiral 1,1'-bi-2-naphthol solutions were obtained with submicron spatial resolution. Three-dimensional sectioning capability of our microscope was also demonstrated. This optically active SFG microscopy can potentially become a powerful imaging...

1-(2-Pyridylazo)-2-naphthol has been used for extraction concentration of palladium, copper, cobalt and nickel from aqueous solutions and subsequent separation of the chelates obtained, by means of high-pressure liquid chromatography. A technique for determining microamounts of palladium in aqueous solutions in the presence of 100-fold ratio of copper and 80-fold ratio of cobalt has been develo...