mina ranjbaran neuroscience research center, baqiyatallah (a.s.) university of medical sciences, tehran, iran. * corresponding author: hedayat sahraei1, phd. neuroscience research center, baqiyatallah (a.s.) university of medical sciences, tehran, iran. tel: +98-21- 26127286 e-mail: [email protected] in the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. in this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. however, no positive results obtained in drug addiction treatment. it seems that more brain systems other than brain reward system must be considered in this regard. article info: hedayat sahraei neuroscience research center, baqiyatallah (a.s.) university of medical sciences, tehran, iran. * corresponding author: hedayat sahraei1, phd. neuroscience research center, baqiyatallah (a.s.) university of medical sciences, tehran, iran. tel: +98-21- 26127286 e-mail: [email protected] in the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. in this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. however, no positive results obtained in drug addiction treatment. it seems that more brain systems other than brain reward system must be considered in this regard. article info:

Ai-Ho Liao Hsin-Yi Chou Yi-Lei Hsieh Sheng-Chieh Hsu Kuo-Chen Wei Hao-Li Liu