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The use of polymeric nanoparticles as drug delivery devices is becoming increasingly prevalent in a variety of therapeutic applications. Despite their widespread clinical use, the factors influencing the release profiles of nanoparticle-encapsulated drugs are still not quantitatively understood. We present here a new, semi-empirical model of drug release from polymeric nanoparticles using a for...

The clinical applications of platinum-based antitumor agents are still largely limited by severe side effects as well as multidrug resistance (MDR). To solve these problems, we developed an 1,2-diaminocyclohexane-platinum(II) (DACHPt)-loaded nanoparticle (NP-TPGS-Pt) by self-assembly of poly(amidoamine)-polyglutamic acid-b-D-α-tocopheryl polyethylene glycol 1000 succinate (PAM-PGlu-b-TPGS) and ...

Before using nanoparticles for therapeutic applications, it is necessary to comprehensively investigate nanoparticle effects, both in vitro and in vivo. In the associated research article [1] we generate multimodal polymeric nanoparticles functionalized with an antibody, that are designed to deliver an anti-oxidant to astrocytes. Here we provide additional data demonstrating the effects of the ...

address correspondence to: Prof. Carlos Rinaldi, Po Box 9046, Mayagüez, PR 00681. tel: 787-832-4040 ext 3585 • Fax: 787-265-3818 • email: crinaldi@ uprm.edu Nanoparticle systems are an intense subject of research for various biomedical applications. Colloidal suspensions of magnetic nanoparticles are of special interest, particularly in bioimaging, and more recently, in Magnetic Fluid Hyperther...

Resistive switching devices have garnered significant consideration for their potential use in nanoelectronics and non-volatile memory applications. Here we investigate the nonlinear current-voltage behavior and resistive switching properties of composite nanoparticle films comprising a large collective of metal-insulator-metal junctions. Silver nanoparticles prepared via the polyol process and...

We demonstrate theoretically the trapping and manipulating of a gold nanoparticle dimer, using surface plasmon excited by a focused linearly-polarized laser beam on a silver film. We use both finite-difference time-domain force analysis and Maxwell stress tensor to show that the gold nanoparticle dimer can be trapped by a virtual probe pair. A formula is derived to represent the plasmonic field...

We demonstrate a simple one-step method for synthesizing noble metal nanoparticle embedded free standing polydimethylsiloxane (PDMS) composite films. The process involves preparing a homogenous mixture of metal salt (silver, gold and platinum), silicone elastomer and the curing agent (hardener) followed by curing. During the curing process, the hardener crosslinks the elastomer and simultaneous...

The equilibrium behavior of ellipsoidal Janus nanoparticles adsorbed at spherical oil/water interfaces was investigated using dissipative particle dynamics simulations. Several phenomena were documented that were not observed on similar simulations for planar oil/water interfaces. The nanoparticles were found to yield isotropic, radial nematic phases, and axial nematic domains, depending on the...

In this work, a theoretical model describing the interaction between a positively or negatively charged nanoparticle and neutral zwitterionic lipid bilayers is presented. It is shown that in the close vicinity of the positively charged nanoparticle, the zwitterionic lipid head groups are less extended in the direction perpendicular to the membrane surface, while in the vicinity of the negativel...