Introduction: Nigella sativa, also known as black seed, cumin, and/or Habbatul Barakah, is a medicinal herbal plant. Thymoquinone (TQ), one of sativa's active ingredients, has been shown to be anticarcinogenic, anti-inflammatory, analgesic, and antimicrobial. Hydroxyapatite (HA) an inorganic mineral with the apatite lattice structure (A10(BO4)6C2). The aim current study incorporate thymoquinone...

Abstract: Background: Bacterial meningitis is a serious medical disorder that should be treated as soon possible. Aim: The effect of ansamycin nanoformulation on Escherichia coli induced was investigated. Materials and Methods: By injecting directly into the brains Swiss Albino mice, an experimental model established. Results: As expected, TNF-α, IL-6, IL-10 secretion stimulated, following neut...

Enzyme replacement therapies (ERT) have been of great help over the past 30 years in treatment various lysosomal storage disorders, including chronic pancreatitis and its common complication, exocrine pancreatic insufficiency. Research shows that difficulties designing such drugs can be overcome by using appropriate additives enzyme immobilization techniques. Cyclodextrins (CDs) considered as a...

Hollow mesoporous-SiO2 nanocapsules have been synthesized at room temperature using unmodified cowpea Mosaic Virus (CPMV) as a template, and without using any catalyst or surfactant during the synthesis. The average size of the capsules synthesized was ∼200-250 nm with a 60-100 nm hollow core. The resulting nanocapsules were characterized using high resolution transmission electron microscopy (...

In order to improve the therapeutic efficacy and minimize the side effects of lung cancer chemotherapy, the formulation of paclitaxel-loaded poly(glycolide-co-ε-caprolactone)-b-D-α-tocopheryl polyethylene glycol 2000 succinate nanoparticles (PTX-loaded [PGA-co-PCL]-b-TPGS2k NPs) was prepared. The novel amphiphilic copolymer (PGA-co-PCL)-b-TPGS2k was synthesized by ring-opening polymerization an...

Peptide therapeutics hold great promise for the treatment of cancer due to low toxicity, high specificity, and ease of synthesis and modification. However, the unfavorable pharmacokinetic parameters strictly limit their therapeutic efficacy and clinical translation. Here, we tailor-designed an amphiphilic chimeric peptide through conjugation of functional 3-diethylaminopropyl isothiocyanate (DE...