Silymarin recognized for numerous activities, but the use is limited due to poor aqueous solubility, inefficient intestinal permeability, and low-erratic bioavailability. The aim of current research was formulation spray-dried nanoemulsion enhance solubility silymarin. prepared by titration method, spray died characterized thermal analysis diffraction scanning calorimetry, crystallography x-ray...

The bibliometric data were extracted from the Scopus database to investigate conceptual framework of ocular nanoemulsion and/or in-situ gel drug delivery system using “ocular” AND “nanoemulsion” OR “in-situ gel” keywords. evaluated with RStudio and VOSviewer program. results reveal that publication trends tend increase continually. India is most impactful country, constructive institution Depar...

This work aimed to prepare a nanoemulsion preparation containing budesonide and assess its aerodynamic behavior in comparison with suspension of budesonide. In-vitro aerodynamic performance of the corresponding micellar solution (ie. nanoemulsion preparation without oil) was investigated too. Nanoemulsions of almond oil containing budesonide, as a hydrophobic model drug molecule, were prepared ...

Nanoemulsion is an alternative and promising approach to overcome insolubility and bioavailability problems of bioactive compounds. In this study, the sonication parameter for preparing nanoemulsions with high α- tocopherol and linolenic acid content were optimized by using response surface methodology and their stability were evaluated during 2 months’ storage. The response surface analysis re...

Garlic bulbs (Allium sativum L.) has an active substance in the form of allicin which is thermolabil, as main antioxidant that can prevent free radicals. Nanoemulsion a particle size 20-500 nm oil and water dispersion system stabilized by combination surfactant cosurfactant. The purpose this study was to obtain best formula from variation VCO concentration 3%, 5%, 8% determine stability nanoemu...

Moringa leaves (Moringa oleifera L.) are a good source of natural antioxidants because they contain flavonoids. The purpose this study was to determine whether leaf extract can be formulated into nanoemulgel serum preparations, and see the effect formulations on antioxidant activity. This research begins with manufacture extracts using maceration method, followed by nanoemulsions. nanoemulsion ...

Background: Oleoresin capsicum (OC) is an organic extract from fruits of the genus Capsicum, and has been reported to have an anti-obesity effect. Objective: This study comparatively investigated lipolytic effects of single-layer nanoemulsion (SN) and alginate double-layer nanoemulsion (AN) containing OC in 3T3-L1 adipocytes. Methods: SN and AN were compared by analyzing the intracellular lipid...

BACKGROUND Respiratory syncytial virus (RSV) is a leading cause of bronchiolitis and pneumonia in young children worldwide, and no vaccine is currently available. Inactivated RSV vaccines tested in the 1960's led to vaccine-enhanced disease upon viral challenge, which has undermined RSV vaccine development. RSV infection is increasingly being recognized as an important pathogen in the elderly, ...