The regioselective polyfunctionalization of highly symmetric spherical I h -C 60 is extremely challenging and usually leads to the formation regioisomeric mixtures not amenable for high-pressure liquid chromatography (HPLC) purification. Here, we pioneer use tetragonal prismatic nanocapsules perform selective Diels-Alder (DA) functionalization encapsulated using acenes. supramolecular mask allo...

Simple and sensitive methods using high-performance liquid chromatography-diode array detection (HPLC-DAD) and ultraviolet (UV)-spectrophotometry were developed and compared to quantify lychnopholide (LYC) in poly-ε-caprolactone nanocapsules and to study its release kinetics. Both methods were validated concerning their specificity, linearity, limits of detection and quantification, precision, ...

Introduction Increasing demands in precise control over delivery and functionalization of therapeutic agents for tumor-specific chemotherapy have led to a rapid development in nanocarriers. Herein, we report a nanocapsule (NC) system for tumor-oriented drug delivery and effective tumor therapy. Materials and methods Functionalized hyaluronan is utilized to build up the NC shells, in which bio...

The kinetics of the self-assembly of nanocomponents into a virus, nanocapsule, or other composite structure is analyzed via a multiscale approach. The objective is to achieve predictability and to preserve key atomic-scale features that underlie the formation and stability of the composite structures. We start with an all-atom description, the Liouville equation, and the order parameters charac...