There is considerable interest in developing nanohybrids of imaging contrast agents and drugs for image-guided drug delivery. We have developed a strategy of utilizing manganese (Mn) to enhance the nano-encapsulation of arsenic trioxide (ATO). Formation of arsenite (As(3+))-Mn precipitates in liposomes generates magnetic susceptibility effects, reflected as dark contrast on T2-weighted MRI. Int...

Photodynamic therapy (PDT) uses the combination of non-toxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided man...

Liposomes, as biocompatible and safe nanocarriers with easily modified surfaces, can be well used in the field of antitumor. Their targeting properties have contributed to reduction drug dosage non-target cell toxicity. To further exploit liposomes, passive active liposomes physicochemical been constructed by surface modification. This paper summarizes mechanisms action different types targeted...

Ocular drug delivery is the most fascinating and challenging task faced by pharmaceutical researchers. One of the major barriers of ocular medication is to obtain and maintain a therapeutic level at the site of action for prolonged periods of time. Major problems encountered by conventional ocular dosage forms include rapid pre-corneal drug loss due to naso-lacrimal drainage; tear turnover and ...

Exosomes are nano-sized vesicles that facilitate intercellular communications through carrying genetic materials and functional biomolecules. Owing to their unique size and structure, exosomes have emerged as a useful tool to overcome the limitations of siRNA delivery. The use of exosomes as siRNA delivery vehicles lacks certain disadvantages of the existing foreign delivery systems such as vir...

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The prototype taxane antineoplastic agent paclitaxel, was first isolated from the bark of the Western yew tree in 1971. It and its congener, the semisynthetic derivative docetaxel, display unique pharmacodynamics as mitotic spindle poisons, differing from the vinca alkaloids and colchicine derivatives in that they bind to a distinct site on β-tubulin and promote rather than inhibit microtubule ...

The main purpose of this study was to optimize the preparation of lysozyme nanoliposomes using response surface methodology and measure their stability. The stabilities of lysozyme nanoliposomes in simulated gastrointestinal fluid (SGF), simulated intestinal fluid (SIF), as well as pH, temperature and sonication treatment time were evaluated. Reverse-phase evaporation method is an easy, speedy,...

A significant amount of academic and industrial research efforts are devoted to the encapsulation of active substances within microor nanocarriers. The ultimate goal of core–shell systems is the protection of the encapsulated substance from the environment, and its controlled and targeted release. This can be accomplished by employing “stimuli-responsive” materials as constituents of the capsul...

Copyright: © Suh KS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Nanotechnology in biomedical research has emerged as an interdisciplinary science that has quickly found its own niche in clinical me...