نتایج جستجو برای: nadph

تعداد نتایج: 21368  

Journal: :Neuropathology and applied neurobiology 2004
C W Picanço-Diniz D Boche W Gomes-Leal V H Perry C Cunningham

Nitric oxide (NO) has been implicated in neurotoxicity and cerebral blood flow changes in chronic neurodegeneration, but its activity in the mammalian prion diseases has not been studied in detail. Nicotine adenine dinucleotide phosphate (NADPH)-diaphorase (NADPH-d) histochemistry is a simple and robust histochemical procedure that allows localization of the tissue distribution of NO synthases....

Journal: :The Journal of biological chemistry 1979
R L Hanson

Pyridine nucleotide transhydrogenase was extracted from the membrane fraction of Escherichia coli with Triton X-100 and purified i’l-fold by chromatography on DEAE-cellulose and Sepharose 4B in buffers containing detergent. The kinetic mechanism for reduction of I-acetylpyridine adenine dinucleotide (AcPyAD) by NADPH was determined. Plots of reciprocal velocity versus the reciprocal concentrati...

2008
F Jiang G Zhang I Hashimoto B S Kumar S Bortolotto W A Morrison G J Dusting

Using an in vivo arterio-venous loop-containing tissue-engineering chamber, we have created a variety of vascularized tissue blocks, including functional myocardium. The viability of the transplanted cells is limited by the rate of neovascularization in the chamber. A Nox2-containing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is thought to have a critical role in ischaemic angi...

Journal: :Journal of molecular and cellular cardiology 2006
Sachin A Gupte Robert J Levine Rakhee S Gupte Martin E Young Vincenzo Lionetti Volodymyr Labinskyy Beverly C Floyd Caroline Ojaimi Michelle Bellomo Michael S Wolin Fabio A Recchia

In the failing heart, NADPH oxidase and uncoupled NO synthase utilize cytosolic NADPH to form superoxide. NADPH is supplied principally by the pentose phosphate pathway, whose rate-limiting enzyme is glucose 6-phosphate dehydrogenase (G6PD). Therefore, we hypothesized that cardiac G6PD activation drives part of the excessive superoxide production implicated in the pathogenesis of heart failure....

Journal: :Neuroscience research 2004
Marco Aurélio M Freire Walace Gomes-Leal Walther A Carvalho Joanilson S Guimarães João G Franca Cristovam W Picanço-Diniz Antonio Pereira

The distribution of NADPH diaphorase (NADPH-d)/nitric oxide synthase (NOS) neurons was evaluated during the postnatal development of the primary somatosensory cortex (SI) of the rat. Both cell counts and area measurements of barrel fields were carried out throughout cortical maturation. In addition, NADPH-d and cytochrome oxidase (CO) activities were also compared in both coronal and tangential...

Journal: :The American journal of physiology 1999
A Obeso A Gómez-Niño C Gonzalez

The aim of the present work was to elucidate the role of NADPH oxidase in hypoxia sensing and transduction in the carotid body (CB) chemoreceptor cells. We have studied the effects of several inhibitors of NADPH oxidase on the normoxic and hypoxia-induced release of [3H]catecholamines (CA) in an in vitro preparation of intact CB of the rat and rabbit whose CA deposits have been labeled by prior...

2013
Jie Jiang Hongjun Kang Xiaoliang Song Sichao Huang Sha Li Jun Xu

Some apocynin analogues have exhibited outstanding inhibition to NADPH oxidase. In this study, the key interactions between apocynin analogues and NADPH oxidase were analyzed by the docking method. The potential active site was first identified by the SiteID program combining with the key residue CYS378. Afterwards, the compounds in the training set were docked into NADPH oxidase (1K4U) under s...

2013
Mark F. McCarty

There are a number of reports that NADPH oxidase activity is elevated in human pancreatic ductal adenocarcinomas (PDAs), or cell lines derived therefrom, and that the resultant production of superoxide protects the cancer from apoptosis. Recently, Du and colleagues have reported that oncogenic mutants of K-Ras – expressed in over 90% of such cancers – promote NADPH oxidase activity via inductio...

Journal: :Journal of general microbiology 1983
P M Bruinenberg J P van Dijken W A Scheffers

Candida utilis CBS 621 was grown in chemostat cultures at D = 0.1 h-1 on glucose, xylose, gluconate, acetate, or ethanol as the growth-limiting substrate with ammonia or nitrate as the nitrogen source and analysed for NADPH-producing and NADPH-consuming enzyme activities. Nitrate and nitrite reductases were strictly NADPH-dependent. For all carbon sources, growth with nitrate resulted in elevat...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1984
H N Kirkman G F Gaetani

Catalases (H2O2:H2O2 oxidoreductase, EC 1.11.1.6) from many species are known to be tetramers of 60,000-dalton subunits, with four heme groups per tetramer. Previous authors have determined the amino acid sequence and three-dimensional structure of bovine liver catalase. Studies of the regulation of the pentose phosphate pathway led the present authors to a search for proteins that bind NADP+ a...

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