N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHDF2, which recognizes m(6)A and reduces the stability of target transcripts. Looking at additional...

We consider directed strongly regular graphs de2ned in 1988 by Duval. All such graphs with n vertices, n6 20, having a vertex-transitive automorphism group, are determined with the aid of a computer. As a consequence, we prove the existence of directed strongly regular graphs for three feasible parameter sets listed by Duval. For one parameter set a computer-free proof of the nonexistence is pr...

We give a randomized algorithm using O(n7 log’ n ) separation calls to approximate the volume of a convex body with a fixed relative error. The bound is O(n6 log4 n ) for centrally symmetric bodies and for polytopes with a polynomial number of facets, and O(n5 log4 n ) for centrally symmetric polytopes with a polynomial number of facets. We also give an O(n6 log n ) algorithm to sample a point ...

We propose a simple fast spectral method for the Boltzmann collision operator with general collision kernels. Compared with the direct spectral method [8] which requires O(N6) memory to store precomputed weights and has O(N6) numerical complexity, the new method has complexity O(MN4 logN), where N is the number of discretization points in each velocity dimension, M is the total number discretiz...

To solve the toxicity issues related to lead-based halide perovskite solar cells, lead-free double Cs2AgBiBr6 is proposed. However, reduced rate of charge transfer in perovskites affects optoelectronic performance. We designed a series pyridine-based small molecules with four different arms attached pyridine core as hole-selective materials by using interface engineering. quantified how arm mod...

The MnBr2 complex of N2,N6-bis-(di-tert-butyl-phosphan-yl)pyridine-2,6-di-amine (1·MnBr2) co-crystallizes with 5.69% of the monophosphine oxide analogue (1O·MnBr2) and two tetra-hydro-furan (THF) mol-ecules, namely [N2,N6-bis-(di-tert-butyl-phosphan-yl)pyridine-2,6-di-amine]-dibromido-manganese(II)-[bis-(di-tert-butyl-phosphan-yl)({6-[(di-tert-butyl-phosphan-yl)amino]-pyridin-2-yl}amino)-phosph...