The structures of 5-aminolaevulinic acid dehydratase complexed with two irreversible inhibitors (4-oxosebacic acid and 4,7-dioxosebacic acid) have been solved at high resolution. Both inhibitors bind by forming a Schiff base link with Lys 263 at the active site. Previous inhibitor binding studies have defined the interactions made by only one of the two substrate moieties (P-side substrate) whi...

Some Copper(II)-Manganese(II) trinuclear complexes of Schiff bases derived from 2aminobenzaldehyde and diamines are reported and characterized based on their elemental analyses, conductivity studies, IR, UV-Visible, ESR spectroscopy and cyclic voltammetric studies. The complexes are found to have the formula [Mn(CuL)2](CH3COO)2. The elemental analyses data confirms the formation of trinuclear c...

A marine arenicin-3 derivative, N4, displayed potent antibacterial activity against Gram-negative bacteria, but its antibacterial mode of action remains elusive. The mechanism of action of N4 against pathogenic Escherichia coli was first researched by combined cytological and transcriptomic techniques in this study. The N4 peptide permeabilized the outer membrane within 1 min, disrupted the pla...

Palladium-catalyzed cross-coupling of (di)chloropyrazines with phosphorus pronucleophiles in the presence of a base gave the phosphorylated pyrazines in 81-95% yields. Based on this methodology a series of appropriately functionalized pyrazines was prepared as potential extractants of trivalent cations from highly acidic nuclear waste. A few hydrophilic derivatives exhibited a very good selecti...

The DNA base composition, including the minor base content, of 26 strains of bacteria was determined. The studied bacteria are sources of widely used restriction endonucleases. Approximately 35% of the bacterial DNAs contained N4-methylcytosine, about 60% contained 5-methylcytosine, and about 90% had N6-methyladenine.

In this paper, an efficient method for synthesis of aromatic polyesters containing schiff base units is described by preparation of two polyesters. These polyesters have been prepared by the reaction of terephthaloyl dichloride on Schiff bases derived from p-hydroxybenzyldehyde and 4,4-diamino diphenyl ether, 4,4-diamino diphenyl methane. The Polymers were characterized by IR, CHNS, thermal...

A novel azo-Schiff base ligand (L) was prepared by reacting 2-hydroxy-5-(pyridine-4-yldiazenyl) benzaldehyde with 1,2-phenylenediamine. Moreover, Silver nanoparticles (Ag-NPs) and Cadmium sulfide nanoparticles (CdS-NPs) were prepared by employing azo-Schiff base ligand (L) as capping and reducing agent. The solid-state fluorescence spectroscopy was used to investigate the interaction between L ...

Schiff base complexes of transition metals are of particular interest to inorganic chemists because of their structural, spectral and chemical properties, which are often strongly dependant on the nature of the ligand structure. Large number of metal (II) complexes with Schiff-base ligands has been extensively studied for their interesting structural specialties, applications and properties. Th...

The copper-catalyzed [3+2] azide-alkyne cycloaddition and the Staudinger ligation are readily applicable and highly efficient for the immobilization of cobalt Schiff base complexes onto polystyrene resins. Stepwise synthesis of polymer-bound Schiff bases followed by their subsequent complexation with metal ions were successfully carried out. Direct covalent attachment of preformed homogeneous c...