Perinatal hypoxia is one of the more common complications early adaptation period. This condition defined as a disorder tissue oxygenation during labour and responsible for approximately 23% neonatal mortality. can cause injury failure many organs, including brain, heart kidneys, mainly in mechanism ischaemic-reperfusion injury. Currently, biochemical markers are frequently incorporated diagnos...

AIMS The degree of systolic dysfunction does not always correlate with functional impairment in patients with congestive heart failure. In contrast, diastolic dysfunction correlates well with functional impairment. In heart failure, both elevation of N-terminal proatrial natriuretic peptide and B-type natriuretic peptide are markers of a poor prognosis. METHODS We investigated 32 patients (26...

Plasma brain natriuretic peptide (BNP), released from myocytes of ventricles upon stretch, has been reported to differentiate pulmonary from cardiac dyspnoea. Limited data have shown elevated plasma BNP levels in acute pulmonary embolism (APE), frequently accompanied by dyspnoea and right ventricular (RV) dysfunction. The aim of this study was to assess plasma N-terminal proBNP (NT-proBNP) in A...

Aim. The present study was designed to test the hypothesis that the development of postinfarction heart failure is associated with a change of activity of the intracardiac oxytocinergic system. Methods. Experiments were performed on male Sprague-Dawley rats subjected to myocardial infarction or sham surgery. Four weeks after the surgery, blood samples were collected and the samples of the left ...

Haemodialysis And New Cardiac Markers Evaluation (CHANCE) study. Nephrol Dial Transplant 2001;16:1452–1458. 41. Singh HS, Bibbins-Domingo K, Ali S, Wu AH, Schiller NB, Whooley MA. N-terminal pro-B-type natriuretic peptide and inducible ischemia in the Heart and Soul Study. Clin Cardiol 2009;32:447–453. 42. Staub D, Jonas N, Zellweger MJ, Nusbaumer C, Wild D, Pfisterer ME, Mueller-Brand J, Perru...

BACKGROUND Considerable morbidity and mortality are still associated with congestive heart failure (CHF) syndromes, despite improvement in therapy. Activation of neurohormonal, inflammatory, and oxidative mechanisms has been shown to contribute to the significant morbidity and mortality. Erythropoietin (EPO) is a cytokine known to regulate erythroid proliferation, attenuate apoptosis and oxidat...

Since the initial observation that elevated cardiac troponin T levels are closely associated with mortality in acute pulmonary embolism,1 several reports have confirmed the prognostic role of cardiac troponins in this setting.2,3 More recently, yet another group of biomarkers, the natriuretic peptides B-type natriuretic peptide (BNP) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP), em...