We describe the first classic example of green synthesis pyrrolo[3,4-c]quinolones scaffolds by catalyst-free unusual reaction diketene, isatin, and primary amines in ethanol presence pyrazole as a promoter for 4 h. The whole structure new product was confirmed X-ray analysis. overall transformation involves cleavage generation multiple carbon-nitrogen carbon-carbon bonds. This report represents...

OBJECTIVE To study the effectiveness of single-dose norfloxacin and ofloxacin in the treatment of gonococcal urethritis in men, and to monitor in vitro antimicrobial susceptibility to these antibiotics over time. SETTING Centre Médico-Social de Bilyogo, Kigali, Rwanda. The only clinic in Rwanda using quinolones for the treatment of gonorrhoea. METHODS As part of a monitoring programme, men ...

A new method of assessing the bactericidal activity of quinolones and other antibacterial agents, known as the bactericidal index or BI, is introduced and discussed. The BI represents total bacterial kill over a drug concentration range limited to levels achievable in vivo. This method allows the bactericidal activity of drugs to be readily compared. Calculation of BI produces a single value pe...

BMS-284756 (T-3811) is a novel quinolone that lacks a fluorine at the C-6 position. BMS-284756 has a broad spectrum of antibacterial activity (3, 7). The purpose of the present study was (i) to analyze the in vitro activity of the novel quinolone against mutants of Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus selected with marketed quinolones and (ii) to investiga...

Within the past decade several new fluoroquinolones (norfloxacin, enoxacin, ofloxacin, ciprofloxacin, pefloxacin, temafloxacin and lomefloxacin) have been introduced into therapy. All these agents share a broad spectrum of activity against a variety of pathogens which are covered with low concentrations of the compounds mentioned. Moreover, the quinolones share the advantage that they are so fa...