نتایج جستجو برای: myometrium

تعداد نتایج: 2097  

Journal: :Toxicology and applied pharmacology 2005
Dong-Il Kim Tae-Kyun Lee Ig-Seob Lim Hwa Kim Young-Choon Lee Cheorl-Ho Kim

Scutellaria barbata D. Don (Lamiaceae) (SB) is a perennial herb, which is natively distributed throughout Korea and southern China. This herb is known in traditional Chinese Medicine as Ban-Zhi-Lian and traditional Korean medicine as Banjiryun, respectively. SB has been used as an anti-inflammatory and antitumor agent. We aimed to determine the expression of growth factor molecules for growth i...

2016
Iain L. O. Buxton Craig Ulrich Scott D. Barnett Heather R. Burkin

Objective: Preterm labor is defined as labor prior to 37 weeks of gestation. There are no FDA approved drugs available to treat spontaneous preterm labor. Uterine smooth muscle is unique in that it relaxes in a cGMPindependent manner in the presence of nitric oxide (NO). However, NO-mediated relaxation in tissues from mothers who deliver preterm is blunted. S-nitrosation of cysteines via NO act...

Amir Hussein Asgari safdar, Hussein Daghigh Kia Ramin Farhadi

Labor is a physiological event involving a sequential, integrated set of changes within the myometrium, deciduas, and uterine cervix that occur gradually over a period of days to weeks. Biochemical connective tissue changes in the uterine cervix appear to precede uterine contractions and cervical dilation, and all of these events usually occur before rupture of the fetal membranes. In other wor...

Journal: :The Journal of endocrinology 2003
H Cárdenas W F Pope

Two experiments were performed to examine the expression of the androgen receptor (AR) gene in the pig uterus. In experiment 1, immunohistochemistry (IHC) was used to determine the distribution of the AR in uterine tIssue of pigs when collected at the first day of estrus (day 0) and the mid-luteal phase (day 12) of the estrous cycle, or early pregnancy (day 12, n=4 gilts per group). In experime...

2014
Tsai-Der Chuang Omid Khorram

We have previously reported that leiomyoma expressed lower levels of miR-200c and elevated IL8 as compared to paired myometrium. Here we addressed the regulatory functions of miR-200c on the expression of inflammatory mediators and cellular viability using leiomyomas and paired myometrium and their isolated primary smooth muscle cells. Our results indicated that gain-of function or knockdown of...

Journal: :Cellular & molecular biology letters 2005
Beata Modzelewska Anna Kostrzewska

Nitric oxide (NO) is a potent inhibitor of spontaneous contractions of the human non-pregnant myometrium; however, the precise mechanism by which NO causes the myometrial smooth muscles to relax remains unclear. The aim of this study was to determine the influence of methylene blue (MB) on myometrial contractions and the response of the myometrium to DEA/NO in vitro. Concentration-response curv...

2017
Glauco R. Souza Hubert Tseng Jacob A. Gage Arunmani Mani Pujan Desai Fransisca Leonard Angela Liao Monica Longo Jerrie S. Refuerzo Biana Godin

Deregulation in uterine contractility can cause common pathological disorders of the female reproductive system, including preterm labor, infertility, inappropriate implantation, and irregular menstrual cycle. A better understanding of human myometrium contractility is essential to designing and testing interventions for these important clinical problems. Robust studies on the physiology of hum...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Masanori Ono Tetsuo Maruyama Hirotaka Masuda Takashi Kajitani Takashi Nagashima Toru Arase Mamoru Ito Kuniaki Ohta Hiroshi Uchida Hironori Asada Yasunori Yoshimura Hideyuki Okano Yumi Matsuzaki

Over the course of pregnancy, the human uterus undergoes a 500- to 1,000-fold increase in volume and a 24-fold increase in weight. The uterine smooth muscle layer or myometrium is remodeled, and both cell hypertrophy and hyperplasia are evident. The origin of the new smooth muscle cells, however, is unclear. They may arise from existing smooth muscle cells, or they may be the product of stem ce...

1999
C. BENASSAYAG M. J. LEROY J. C. HONORÉ T. M. MIGNOT M. C. VACHER-LAVENU F. FERRÉ

Benassayag, C., M. J. Leroy, V. Rigourd, B. Robert, J. C. Honoré, T. M. Mignot, M. C. Vacher-Lavenu, C. Chapron, and F. Ferré. Estrogen receptors (ERa/ERb) in normal and pathological growth of the human myometrium: pregnancy and leiomyoma. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E1112–E1118, 1999.—The distributions of the mRNAs for estrogen receptors (ERa and ERb) and their binding propert...

Journal: :Physiological research 2002
H Celik A Ayar

Erythromycin has a well-known dual effect on the contractility of the gastrointestinal system and recently has also been shown to inhibit contractions of the rat myometrium. The aim of the present study was to investigate the effects of clarithromycin on oxytocin, prostaglandin F2alpha (PGF2alpha) and KCl-induced contractions of human myometrium in vitro. Myometrial strips were obtained from pr...

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