Malignant phyllodes tumors of the breast are aggressive, occurring less frequently than fibroadenomas. The diagnosis is established after excluding metaplastic carcinoma and sarcomas. A 47 year old woman presented a primary tumor composed of hyperplastic epithelial and mucoid component, typically seen in fibroadenomas. Further investigations revealed PanCK, EMA and CK8/18 stained epithelial cel...

UNLABELLED Bronchial mucoepidermoid tumors are uncommon neoplasms, morphologically similar to their salivary gland counterpart. The histogenesis is controversial. The aim of this study is to identify myoepithelial cells and speculate on their role in the origin of these tumors. METHODS AND RESULTS Sixteen bronchial mucoepidermoid tumor surgical specimens were formalin-fixed, paraffin-embedded...

BACKGROUND Myoepitheliomas are uncommon salivary gland neoplasms consisting entirely or predominantly of cells with myoepithelial phenotype. They commonly involve the parotid gland and the minor salivary glands of the palate. AIM A case of plasmacytoid myoepithelioma of the hard palate is described. CASE DESCRIPTION AND RESULTS A 55-year-old woman presented to her oral surgeon with a tumor ...

Normal mammary epithelial cells express the cell surface protein biliary glycoprotein (BGP or CD66a) in a polarized manner, suggesting that this protein may play a role in the formation of mammary acini. In order to test this hypothesis, we interrupted the expression of BGP in the mammary epithelial line MCF10F when cultured in or on Matrigel, a source of extracellular matrix (ECM). When analyz...

a 41 year old woman was referred to our center because of a left breast mass lesion of about two months duration. routine pathologic examination of the mass revealed a .neoplastic tissue composed of large ovoid cells with clear cytoplasm arranged in broad sheets that were separated by thin bundles of connective tissue. immunohistochemically tumor cells express smooth muscle actin, cytokeratin, ...

A series of cell lines was isolated from the metastasizing rat mammary tumor cell strain TMT-081. MS by single-cell cloning. Feeder cells were required for development of single tumor cells into clonal colonies. The rate, pattern, and incidence of metastases following injection of cells into the mammary fat pads of syngeneic rats were relatively similar for the various cell lines, with dissemin...

In adult females, the mammary epithelium is organized in two layers, a luminal epithelium and a basal layer, consisting of myoepithelial cells. Undifferentiated precursors of both luminal and myoepithelial cells are also believed to be basally localized. The mammary epithelium bilayer is surrounded by a basement membrane embedded in connective tissue. In the fully differentiated mammary gland, ...