We studied the expression of hypoxia-related antigens (e.g., cold-inducible antigens and apoptotic antigens) in the myocardium and the cerebellumthat were obtained from individuals after death by carbon monoxide or hypothermia. The immunohistochemistry results revealed that expression of cold-inducible RNA binding protein (CIRBP) and RNA-binding protein 3 (RBM3) may be associated with hpyotherm...

Brief episodes of myocardial ischemia-reperfusion (IR) employed during reperfusion after a prolonged ischemic insult may attenuate the total ischemia-reperfusion injury. This phenomenon has been termed ischemic postconditioning. In the present study, we studied the possible effect of ischemic postconditioning on an ischemic reperfusion (IR)-induced myocardium oxidative injury in rat model. Resu...

The myocardium of the left ventricle (LV) of the heart comprises layers of muscle fibers whose orientation varies through the heart wall. Because of these fibers, accurate modeling of the myocardium stress-strain behavior requires models that are nonlinear, anisotropic, and time-varying. This article describes the development and testing of a material model of the canine LV myocardium, which wi...

Background: Radiation-induced cardiac events and pneumonitis are the major late radiotherapy side effects. Methods: We explored differences in dose distribution between 3D CRT, IMRT VMAT 125 women with unilateral breast cancer. The various to tumor OARs were studied for left right sided irradiation. Results: Upon using CRT breasts lymph nodes, we observed a significant increase ipsilateral lung...

Objective: We have previously demonstrated that myocardium is capable of down-regulating its 0, requirements and thus avoiding ischaemia when 0, supply is limited. The present study tested the hypothesis that endogenous adenosine produced this protective response when 0, supply was decreased by moderate coronary hypoperfusion or moderate coronary hypoxaemia. Methods: In anaesthetised dogs, hear...