نتایج جستجو برای: myocardial ischemic reperfusion injury

تعداد نتایج: 520115  

Journal: :Circulation research 1992
G Takemura T Onodera M Ashraf

To elucidate the pathophysiological role of the hydroxyl radical (.OH) during the postischemic reperfusion of the heart, we measured the .OH product in the coronary effluent from isolated perfused rat heart during a 30-minute reperfusion period after various ischemic intervals of 5, 10, 15, 20, 30, and 60 minutes. Salicylic acid was used as the probe for .OH, and its derivative, 2,5-dihydroxybe...

Journal: :Journal of immunology 2000
N G Frangogiannis L H Mendoza M L Lindsey C M Ballantyne L H Michael C W Smith M L Entman

Reperfusion of the ischemic myocardium is associated with a dramatic inflammatory response leading to TNF-alpha release, IL-6 induction, and subsequent neutrophil-mediated cytotoxic injury. Because inflammation is also an important factor in cardiac repair, we hypothesized the presence of components of the inflammatory reaction with a possible role in suppressing acute injury. Thus, we investig...

2016
Gerd Heusch

Reperfusion is mandatory to salvage ischemic myocardium from impending infarction. However, reperfusion also causes additional irreversible injury, not only to the myocardium, but also to the coronary microcirculation. Such reperfusion injury is the target of cardioprotective conditioning strategies. Such strategies include brief cycles of ischemia/reperfusion before (preconditioning), during (...

Journal: :International journal of clinical and experimental pathology 2015
Satwat Hashmi Suhail Al-Salam

Myocardial infarction (MI) denotes the death of cardiac myocytes due to extended ischemia. Myocardial reperfusion is the restoration of coronary blood flow after a period of coronary occlusion. Reperfusion has the potential to salvage ischemic myocardium but paradoxically can cause injury, a phenomenon called as 'reperfusion injury' (IR). Standard histologic, immunohistochemical and Elisa techn...

2010
Yon Hee Shim

With an increase in the elderly population and an increase in the prevalence of age-related cardiovascular disease, anesthesiologists are increasingly being faced with elderly patients with known or suspected ischemic heart disease in the perioperative period. Although early reperfusion remains the best strategy to reduce ischemic injury, reperfusion may damage the myocardium. Adjuvant therapy ...

2012
Ahmet Mahli Demet Coskun

Myocardial protection with cardioplegia has resulted in significant improvement in the outcomes of cardiopulmonary bypass (CPB) in coronary artery bypass graft (CABG) procedure. However, subendocardial damage created by ischemic injury still remains a source of morbidity and mortality associated with CABG (1). Ventricular fibrillation (VF) occurring after releasing of aortic cross-clamp in the ...

Journal: :The American journal of physiology 1999
Vincent M Figueredo Ivan Diamond Hui-Zhong Zhou S Albert Camacho

Sustained protection against ischemia-reperfusion injury is not available for patients at risk for myocardial infarction who may require emergent reperfusion therapy. Whereas ischemic preconditioning and adenosinergic agents reduce myocardial injury, they are only effective when given immediately before ischemia or reperfusion. We recently found chronic ethanol exposure, an adenosine uptake inh...

2016
Nasser Safaei Mohammad Ali Sheikhalizadeh Reza Badalzadeh

INTRODUCTION Reperfusion injury is a well-known phenomenon following restoration of the coronary circulation after coronary artery bypass grafting (CABG) that impairs myocardial function. In order to control the severity of this injury, we aimed to investigate the effect of a new conditioning strategy namely ischemic postconditioning (IPOC) along with controlled aortic root reperfusion (CARR) o...

Journal: :Life sciences 2010
Mahmood Khan Pawel Kwiatkowski Brian K Rivera Periannan Kuppusamy

Myocardial infarction (MI) is caused by deprivation of oxygen and nutrients to the cardiac tissue due to blockade of coronary artery. It is a major contributor to chronic heart disease, a leading cause of mortality in the modern world. Oxygen is required to meet the constant energy demands for heart contractility, and also plays an important role in the regulation of heart function. However, re...

2017
Hongbao Tan Li Chen Jun Ma

Ischemic heart disease is a major cause of mortality and disability worldwide. Timely reperfusion is currently the most effective method of treating ischemic heart disease; however, abrupt reperfusion may cause ischemia/reperfusion (I/R) injury. Apoptosis serves an important role in the progression of myocardial I/R injury and it has been demonstrated that the mitochondria are the center of reg...

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