Previous studies have suggested that hyperglycemia on admission is a risk factor for increased mortality in patients with acute ST-elevation–myocardial infarction (STEMI). However, data regarding the relationship between hyperglycemia and myocardial damage in STEMI are scarce. This largest cardiac magnetic resonance study to date evaluating the relationship of diabetes mellitus status and eleva...

BACKGROUND Revascularization of infarcted myocardium results in release of inflammatory cytokines mediating myocardial reperfusion injury and heart failure. Blockage of inflammatory pathways dampens myocardial injury and reduces infarct size. We compared the impact of the interleukin-1 receptor antagonist Anakinra and erythropoietin on myocardial ischemia/reperfusion injury. In contrast to othe...

This study was to investigate the effect of total flavones of rhododendra (TFR) on ischemic myocardial injury in rabbits. Rabbit ischemic myocardial injury was induced by occluding the anterior descent of the left artery (LAD). The ECG was recorded; the plasma creatine kinase (CK), nitric oxide (NO) and endothelin-1 (ET-1) levels were measured using spectrophotometry, Griess method and radioimm...

RATIONALE Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated. OBJECTIVE We studied the molecular mechanism mediating the effect of GSK-3β activation/inhibition upon myocardial injury during prolonged ischemia and I/R. ...

The maintenance of tissue, organ, and organism homeostasis relies on an intricate network players mechanisms that assist in the different forms cell–cell communication. Myocardial infarction, following heart ischemia reperfusion, is associated with profound changes key processes intercellular communication, involving gap junctions, extracellular vesicles, tunneling nanotubes, some which have be...

Ischemic heart disease (including coronary arterial atherosclerosis, or vascular cavity stenosis or occlusion) remains the leading cause of disease‑associated mortality worldwide. Prazosin, a receptor blocker of postsynaptic adrenaline, is essential in expanding peripheral arteries, which decreases peripheral vascular resistance, and regulates anti‑hypertensive action. However, the mechanisms u...

Following acute myocardial infarction (MI), limitation of infarct size is central to long-term outcome (1). Successful reperfusion results in smaller infarct size and a marked reduction in mortality (1,2). However, following fibrinolytic therapy, ischemic myocardial injury continues during the process of clot lysis. Although reperfusion arrests the acute ischemic injury, it may cause further in...

OBJECTIVES We evaluated the prognostic relevance of the extent of myocardial injury, as measured by a standard electrocardiographic (ECG) method, on the patients' long-term prognosis, its time dependence and its relation to fibrinolytic therapy efficacy. BACKGROUND Many clinical and instrumental variables influence the short- and long-term prognoses of patients with acute myocardial infarctio...