We investigated the protective role of Withania somnifera leaf extract (WSLEt) on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (85 mg/kg body weight (b.w.)) administered to rats for two consecutive days caused a significant increase in cardiac troponin I (cTnI) levels and serum lipid profiles, as well as the activities of some marker enzymes. I...

(1) Background: The aim of our study was to determine the role oxidative stress (OS) during early evaluation acute ST-elevated myocardial infarction (STEMI) and non-ST-elevated (NSTEMI) patients in order define redox balance profiling development (MI). (2) Methods: This prospective observational case-control included 40 consecutive STEMI 39 NSTEMI hospitalized coronary care unit cardiology clin...

BACKGROUND Gualou Xiebai Decoction (GXD) is a well-known traditional Chinese recipe. It has been used to treat cardiovascular disorders for nearly two thousand years. But there is a lack of reports on cardiac fibrosis and underlying mechanism. METHODS Myocardial infarction was performed by ligation of left anterior descending coronary artery (LAD) in male Wistar rats. Rats with myocardial inf...

OBJECTIVE Using a swine model of acute myocardial ischemia, we sought to validate N-(11)C-methyl-dopamine ((11)C-MDA) as an agent capable of imaging cardiac sympathetic nerve injury. METHODS Acute myocardial ischemia was surgically generated in Chinese minipigs. ECG and serum enzyme levels were used to detect the presence of myocardial ischemia. Paired (11)C-MDA PET and (13)N-ammonia PET scan...

A 30-year-old man visited the emergency room for chest pain, dyspnea and fever. Despite increased serum cardiac enzymes, ST segment elevation and inferior wall akinesis in electrocardiography and echocardiography, no atherosclerosis was evident in the coronary angiography. However, radionuclide myocardial perfusion image at day 2 showed a persistent perfusion defect in the left ventricular (LV)...

• In the past, investigations dealing with biochemical changes accompanying myocardial infarction have been primarily directed toward studies concerning the release of enzymes by the heart muscle.' 2 Studies in dogs have led to the conclusion that the first reaction in myocardial infarction is necrosis followed by infiltration with polymorphonuclear leukocytes; finally collagen formation takes ...

To determine the mechanism of the cardiac dilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed chemically and morphologically. TG was high because of underexpression of fatty acid oxidative enzymes and their transcription factor, peroxisome proliferator-activated receptor-alpha. Levels of ceramide, a mediator of apoptosis, were 2-...