With technological advances, online surveys have become increasingly common, which makes fitness assessment feasible. We aimed to assess the construct validity and test reliability of International Fitness Scale – Brazilian version (IFIS BRA) in format compared printed version. Participants were adolescents (n = 294), aged between 12 17 years, both sexes. Adolescents answered IFIS BRA two momen...

Norcantharidin (NCTD) is a demethylated analogue of cantharidin which is an active ingredient of Chinese medicine-Mylabris. It has been used as an anticancer drug for the treatment of colon cancer, primary hepatoma, carcinomas of esophagus and breast cancer, leukopenia in China for many years (Wang, 1989; Fang et al., 1993). Previous studies have shown that NCTD could suppress the invasion and ...

BACKGROUND Norcantharidin, the demethylated analog of cantharidin derived from a traditional Chinese medicine, Mylabris, has been used in the treatment of anti-cancer effects. However, the detailed mechanisms underlying this process are generally unclear. The aim of this study was to investigate the mechanism of NCTD-induced apoptosis in HepG2 cells. METHODS The cytotoxicity was measured by M...

Cantharidin isolated from Mylabris caraganae and other insects has been used as an anti-cancer drug in China for many years. However, its toxicity on the renal system and suppression effect on bone marrow limits its usage clinically. Based on the core structure of cantharidin, we have chemically synthesized two cantharidin analogues (compounds 2 and 3). The cytotoxic activity of these analogues...

The dried body of Mylabris cichorii is well-known Chinese traditional medicine. The sesquiterpenoid cantharidin, which is secreted mostly by adult male beetles, has recently been used as an anti-cancer drug. However, little is known about the mechanisms of cantharidin biosynthesis. Furthermore, there is currently no genomic or transcriptomic information for M. cichorii. In this study, we perfor...

Resumo Tendo como referência os estudos da história do livro e cultura escrita, o artigo trabalha com a tipografia um dos indicadores de circulação escrita em Minas Gerais, no final século XIX início XX. Tomando fonte anuários, almanaques anúncios são recuperadas algumas condições técnicas das tipografias papel que exercem na relação instâncias livrarias papelarias. A partir é feito inventário ...

Pormenorizar os processos de aquisição do conhecimento é um desafio para pesquisadores das distintas áreas. Considerando a aprendizagem fenômeno que comporta amplitude social e cultural dos indivíduos, as vivências no decorrer da história pessoal podem firmar conjunto conceitual permite retenção conhecimento. Este artigo tem como objetivo avaliar representatividade identidade culturalmente negr...

RESUMO Objetivo: construir e validar conteúdo aparência de álbum seriado sobre insulinoterapia por Sistema Infusão Contínua. Método: estudo metodológico, realizado em três etapas Fortaleza, Ceará, Brasil, nos meses agosto a novembro 2018. Realizou-se construção do validação pelos especialistas, avaliação público-alvo. Calcularam-se Índice Validade Conteúdo Concordância. Resultados: os juízes co...