regulation of normal cell growth and turnover is balanced between cell pro¬liferation, cell differentiation and apoptosis. a disruption of this balance is thought to be an important event leading to carcinogenesis .one of the effector molecules in apoptosis is fas antigen . cross-linking of fas by its ligand (fas l) or agonistic anti fas antibodies induces apoptosis of cells expressing fas on t...

background the induction ofâ  cancers incidence by exogenous agents, such as chemical, radiation and especially research on viruses is an interestedâ  area of active basic subjectsâ  and clinical investigation. prominent researches sounds aâ  high prevalence of hbv marker has been found in patients with leukemia as compared to the general population. methods: presentâ  â study was conducted fro...

background and objectives: bone marrow necrosis (bmn) is a rare and ominous complication of wide variety of diseases including hematologic malignancy. this study was performed to identify frequency and the underlying associated diseases of marrow necrosis. materials and methods: in this descriptive study, totally 850 bone marrow trephine biopsies related to living patients at the pathology depa...

The MN1 oncogene is deregulated in human acute myeloid leukemia and its overexpression induces proliferation and represses myeloid differentiation of primitive human and mouse hematopoietic cells, leading to myeloid leukemia in mouse models. To delineate the sequences within MN1 necessary for MN1-induced leukemia, we tested the transforming capacity of in-frame deletion mutants, using retrovira...

Nerve growth factor (NGF) induces autophosphorylation and downstream progrowth and prosurvival signaling from the receptor tyrosine kinase TrkA. Overexpression or activating mutation of TrkA has been described in human acute myeloid leukemia cells. In the present study, we show the chaperone association of TrkA with heat shock protein 90 (hsp90) and the inhibitory effect of the hsp90 inhibitor,...

We conducted a case-control study to investigate the role of ABCB1 C3435T (rs1045642) and C1236T (rs1128503) gene polymorphisms in the susceptibility to acute myeloid leukemia. The polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP) method was carried out to genotyping ABCB1 C3435T and C1236T gene polymorphism. Statistical analysis was conducted using th...

The PI3K/AKT and mTOR signaling pathways are activated in acute myeloid leukemia, including in the more immature leukemic populations. Constitutive PI3K activation is detectable in 50% of acute myeloid leukemia samples whereas mTORC1 is activated in all cases of this disease. In leukemic cells, the PI3K activity relates to the expression of the p110delta isoform of class IA PI3K. Constitutive P...

The relation between diet, lifestyle, and acute myeloid leukemia was assessed in a US cohort of 491,163 persons from the NIH-AARP Diet and Health Study (1995-2003). A total of 338 incident cases of acute myeloid leukemia were ascertained. Multivariate Cox models were utilized to estimate hazard ratios and 95% confidence intervals. Compared with those for never smokers, hazard ratios were 1.29 (...

Aleukemic leukemia cutis is a rare condition characterized by the invasion of leukemic blasts into the skin before their appearance in the peripheral blood. Leukemia cutis usually occurs in patients with myeloid leukemia, especially the myelomonocytic and monocytic types of acute myeloblastic leukemia. We describe the case of a 62-year-old woman with aleukemic leukemia cutis who developed Phila...

To characterize the biology and optimal therapy of acute mixed-lineage leukemia in children, we reviewed the pathologic and clinical features, including response to therapy, of 35 patients with mixed-lineage leukemia. The majority of cases (91%) had blasts cells that simultaneously expressed either T-lineage plus myeloid markers (T/myeloid, n = 20) or B-lineage plus myeloid markers (B/myeloid, ...