Cancer patients and the providers who care for them are becoming increasingly concerned that cancer treatments may cause longterm cognitive changes that can negatively impact on attainment of educational and work goals and general quality of life. A growing body of literature has suggested that long-term changes in cognitive functioning can be associated with a variety of systemic cancer treatm...

Resolution of Behcet's disease after non-myeloablative allogeneic stem cell transplant for acute myeloid leukaemia SIR, Behcet's disease (BD) commonly affects younger patients. The diagnosis is generally made from a cluster of symptomatol-ogies, including recurrent orogenital ulcers, skin rash, seronega-tive arthritis and uveitis. The diagnosis requires the presence of recurrent oral ulceration...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The treatment for hematological malignancies has excelled over the past decade. A vast number of hema-tological malignancies are now amenable to cure with hematopoietic stem cell transplants (HSCTs) [1]. Older patients with comorbidities are poor candidates ...

Hematopoietic stem cell transplantation (HSCT) involves the transfer of stem cells to establish hematopoiesis in patients who have received myeloablative chemotherapy with or without whole body irradiation. Following high-dose therapy and HSCT, all patients experience a period of neutropenia. Outpatient care delivery models place expanded responsibilities on patients and their families for the ...

Polychemotherapy or radiation frequently causes oral mucositis. Until now, only supportive options are available. Palifermin, a recombinant form of the human keratinocyte growth factor can avoid mucositis in patients treated with myeloablative polychemotherapy for allogeneic stem cell transplantation. Here, we present a patient treated with dose-intense conventional polychemotherapy suffering f...

Autologous haematopoietic stem cell transplantation has been tried as one experimental strategy for the treatment of patients with aggressive multiple sclerosis refractory to other immunotherapies. The procedure is aimed at ablating and repopulating the immune repertoire by sequentially mobilizing and harvesting haematopoietic stem cells, administering an immunosuppressive conditioning regimen,...

Neuroblastoma is the most frequently diagnosed cancer during first year of life. This neoplasm originates from neural crest cells derived sympathetic nervous system, adrenal medulla, or paraspinal ganglia. The clinical presentation can vary an asymptomatic mass to symptoms resulting local invasion and/or spread distant disease spread. natural history neuroblastoma highly variable, ranging relat...

BACKGROUND High dose myeloablative chemotherapy ("megatherapy"), with haematopoietic stem cell support, is now widely used to consolidate response to induction chemotherapy in patients with advanced neuroblastoma. PROCEDURE In this study (European Neuroblastoma Study Group, ENSG1), the value of melphalan myeloablative "megatherapy" was evaluated in a randomised, multi-centre trial. Between 19...

BACKGROUND Long-term immune recovery in older patients given hematopoietic cell transplantation after non-myeloablative conditioning remains poorly understood. This prompted us to investigate long-term lymphocyte reconstitution and thymic function in 80 patients given allogeneic peripheral blood stem cells after non-myeloablative conditioning. DESIGN AND METHODS Median age at transplant was 5...

Acute myeloid leukemia (AML) has posed significant therapeutic challenges to pediatric oncologists. Despite intensive therapy, half of the children with AML relapse and die from their disease. Efforts to identify risk factors in AML are directed toward defining populations who may benefit from alternative therapies. Patients at lower risk for relapse may benefit from treatment de-escalation, sp...