background since tuberculosis (tb) is a major public health problem that is a leading cause of mortality and morbidity among infectious diseases worldwide, early diagnosis and treatment are important to control an effective tuberculosis (tb) and also the increasing number of patients with atypical manifestations of active tb. it suggests more evaluation for active tb in fibrotic lesion in ct sc...

objective(s): tuberculosis is one of the most important infectious diseases with high mortality rates worldwide, especially in developing countries. interleukin17 (il-17) is an important acquired immunity cytokine, which is mainly produced by cd4+th17 cells. it can recruit neutrophils and macrophages to the infected site in the lungs. il-23 is one of the most important inducers of il-17. in the...

background: resistance to anti-tuberculosis (tb) drugs is a global problem. previous studies showed that the prevalence of primary mdr-tb is higher and has been increasing. the purpose of this study was to determine the primary drug resistance in strains isolated from patients with smear-positive of the new cases to anti-tb drugs. methods: in this cross-sectional study, 266 smear positive pulmo...

mycobacterium avium subspecies paratuberculosis (map) is the cause of john’s disease also called paratuberculosis. this is economically one of the important infectious diseases in cattle and ruminant husbandry. this disease is manifested as granulomatosis entrocolitis, lymphadenitis and inflammation local lymphatic vessels. the typical sign of this disease is progressive loss of weight. cons...

The Mycobacterium avium complex (MAC) consists of four recognized species, Mycobacterium avium, Mycobacterium colombiense, Mycobacterium intracellulare and Mycobacterium chimaera, and a variety of other strains that may be members of undescribed taxa. We report on two isolates of a scotochromogenic, slowly growing, non-tuberculous Mycobacterium species within the M. avium complex from a lymph n...

The anti-mycobacterial activities of nine series of dicarboxyl and tricarboxyl dendritic amphiphiles with one alkyl, two alkyl, and cholestanyl tails against Mycobacterium abscessus, Mycobacterium avium, Mycobacterium chelonae, Mycobacterium marinum and Mycobacterium smegmatis have been measured. The dendritic amphiphiles overcame the limited aqueous solubility of natural long-chain fatty acids...

Enzyme-linked immunosorbent assays which are based on species- or type-specific glycolipids antigens and in which rabbit antisera are prepared with homologous strains are capable of distinguishing among serological variants of the Mycobacterium avium-Mycobacterium intracellulare-Mycobacterium scrofulaceum complex, Mycobacterium chelonei subspecies chelonei and abscessus, Mycobacterium simiae I ...

Mycobacterium simiae is a non-tuberculosis mycobacterium causing pulmonary infections in both immunocompetent and imunocompromized patients. We announce the draft genome sequence of M. simiae DSM 44165(T). The 5,782,968-bp long genome with 65.15% GC content (one chromosome, no plasmid) contains 5,727 open reading frames (33% with unknown function and 11 ORFs sizing more than 5000 -bp), three rR...

Identification of Mycobacterium tuberculosis and Rifampin Resistance in Pulmonary Extra-pulmonary Clinical Specimens Using the Gene Xpert MTB/RIF Assay