Dysbindin was identified as a dystrobrevin-binding protein potentially involved in the pathogenesis of muscular dystrophy. Subsequently, genetic studies have implicated variants of the human dysbindin-encoding gene, DTNBP1, in the pathogeneses of Hermansky-Pudlak syndrome and schizophrenia. The protein is a stable component of a multisubunit complex termed BLOC-1 (biogenesis of lysosome-related...

Hermansky-Pudlak syndrome (HPS) is a disorder of organelle biogenesis affecting 3 related organelles-melanosomes, platelet dense bodies, and lysosomes. Four genes causing HPS in humans (HPS1-HPS4) are known, and at least 15 nonallelic mutations cause HPS in the mouse. Where their functions are known, the HPS-associated proteins are involved in some aspect of intracellular vesicular trafficking,...

[1] We analyzed temperature trends from 460 GHCNv2 weather stations in the western United States for 1948–2006 to determine whether the extent of decoupling of surface temperatures from the free atmosphere influences past change. At each location we derived monthly indices representative of anticyclonicity using NCEP/NCAR 700 hPa reanalysis pressure fields. The number of anticyclonic days minus...

Ag presentation to CD8(+) T cells commences immediately after infection, which facilitates their rapid expansion and control of pathogen. This paradigm is not followed during infection with virulent Salmonella enterica serovar Typhimurium (ST), an intracellular bacterium that causes mortality in susceptible C57BL/6J mice within 7 days and a chronic infection in resistant mice (129 x 1SvJ). Infe...

BACKGROUND Exposure to ozone activates innate immune function and causes neutrophilic (PMN) airway inflammation that in some individuals is robustly elevated. The interplay between immuno-inflammatory function and genomic signaling in those with heightened inflammatory responsiveness to ozone is not well understood. OBJECTIVES Determine baseline predictors and post exposure discriminators for...

341 In the first days after a magnitude 8.7 earthquake leveled buildings on the Sumatran islands of Nias and Simeulue on 28 March, experts wondered why it failed to generate a significant tsunami. After all, the monster quake that struck just to the north in Decem-ber spawned a tsunami that killed more than a quarter-million people. Now that they've had a chance to locate the fault rupture more...

The schizophrenia susceptibility gene dystrobrevin-binding protein 1 (DTNBP1) encodes dysbindin, which along with its binding partner Muted is an essential component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Dysbindin expression is reduced in schizophrenic brain tissue, but the molecular mechanisms by which this contributes to pathogenesis and symptomatology are unkno...