Traditionally, Lentinula edodes are used in many Asian countries for the treatment of various chronic diseases. In current study, ethyl acetate fraction fruit body was obtained by standard bioassay-guided fractionation procedure. This resulted isolation three bioactive compounds (compound 1 already reported, compound 2 and 3 first time reported from this mushroom) their structures were characte...

To investigate the physiological functions of polyphenols from acerola (Malpighia emarginata DC.) fruit, the effects on melanogenesis were studied. The crude polyphenol concentrated extract from acerola (C-AP) was used to examine the skin-lightening effect on brownish guinea pigs which had been subjected to controlled UVB irradiation. The results show that C-AP significantly lightened the UVB-i...

The generation of hydroxyl radicals and singlet oxygen during the oxidation of 4-(4-hydroxyphenyl)-2-butanol (rhododendrol) and 4-(3,4-dihydroxyphenyl)-2-butanol (rhododendrol-catechol) with mushroom tyrosinase in a phosphate buffer (pH 7.4) was examined as the model for the reactive oxygen species generation via the two rhododendrol compounds in melanocytes. The reaction was performed in the p...

Solvent extracts of Rhus verniciflua Stokes wood were made using decompressing inner ebullition, and a Box-Behnken design was used to optimize extraction conditions to produce an extract that inhibited tyrosinase activity. The chemical compositions and inhibition rates were determined in extracts made with petroleum ether, ethyl acetate, n-butanol, and an aqueous fractionation. The ethyl acetat...

The study described here was undertaken in an effort to determine whether multiple forms of tyrosinase (EC 1.10.3.1) are present in Fundulus heteroclitus during embryonic development. If they are present, do they appear simultaneously in the course of development and do they continue to be produced and maintained without change during the part of the life cycle when tyrosinase should normally b...

Introduction: Tyrosinase is considered an important target of melanin biosynthesis inhibitors. Curcuma longa L. has been used in the Javanese traditional whitening cosmetics. This work aimed to explore effect C. extracts on mushroom tyrosinase activity and cytotoxicity extract towards murine skin cancer B16F10 cells. Methods: rhizomes were cold-extracted using ethanol 70% yielded 15.3% w/w (ECL...

Background: Tyrosinase is a copper-containing enzyme, which is widely distributed in microorganisms, animals and plants. It is also a key enzyme in melanin biosynthesis, which plays a crucial role in determining the color of mammalian skin and hair. In addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food...

layer of the dermis and is the major cellular component responsible for skin color. Although normal melanin pigmentation in the skin is the major defense mechanism against ultraviolet light, the production of abnormal pigmentation such as melasma, freckles, senile lentigines, and other forms of melanin hyperpigmentation can be a serious problem aesthetically. The novo synthesis of melanin invol...

A mono- and a bi-functional dithiocarbamates as sodium salts were obtained by treating p-peridine or p-perazine in aceton-water mixture with CS2 in the presence of NaOH. These anionic water soluble compounds have been characterized by elemental analysis, IR and 1H NMR spectroscopic studies. Both compounds (p-peridine (I) and p-perazine-bis dithiocarbam...

Abstract Although metal–organic frameworks (MOFs) have been considered as promising matrices for enzyme immobilization, HKUST-1, constructed from copper acetate (CuAc 2 ) and benzene 1,3,5-tricarboxylate (BTC), has rarely explored this application. In study, mushroom tyrosinase (EC 1.14.18.1) was immobilized in the form of tyrosinase@HKUST-1 following a simple reaction procedure by mixing BTC w...